ID   A0A3Q2CYS8_CYPVA        Unreviewed;       719 AA.
AC   A0A3Q2CYS8;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Stonustoxin subunit alpha-like {ECO:0000313|Ensembl:ENSCVAP00000011093.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000011093.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000011093.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the SNTX/VTX toxin family.
CC       {ECO:0000256|ARBA:ARBA00006480}.
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DR   AlphaFoldDB; A0A3Q2CYS8; -.
DR   Ensembl; ENSCVAT00000017979.1; ENSCVAP00000011093.1; ENSCVAG00000013314.1.
DR   GeneTree; ENSGT00390000014380; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR006574; PRY.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR048997; Stonustoxin-like_helical.
DR   InterPro; IPR040581; Thioredoxin_11.
DR   PANTHER; PTHR31594; AIG1-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR31594:SF16; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13765; PRY; 1.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF21109; Stonustoxin_helical; 1.
DR   Pfam; PF18078; Thioredoxin_11; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00589; PRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   3: Inferred from homology;
KW   Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW   Hemolysis {ECO:0000256|ARBA:ARBA00022735};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Toxin {ECO:0000256|ARBA:ARBA00022656}.
FT   DOMAIN          524..719
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
SQ   SEQUENCE   719 AA;  82491 MW;  2952530A98ED2F1E CRC64;
     MMMFGVNSDG KFNCFNSVFS SRNPTFKNKT AVALLFRFFL NYNRFVFFST DFTLWDRETI
     KKFTTRKTQN SSHYETIASD TIAAKTSLLK ADESLTASVL SGLIDVGASA NYLNDKKEFK
     NQSRVILHYK ATTAYERLDL NHQDAKKLQA RDVIKYSHAT HVVTGILYGA NAFFVFDSER
     LDISSLHSME GSMQSLIKKI PKLDPEGNMV RNLREAEKSV MEKVSCKFYG DFILERNPTT
     FEEAADTYRN LPGLLGKDGE KSVPVKIWLS PLKNLDSAAA QLKGSISDVV LRKAENVWEG
     IREIQMRCNE SLEGDVVKTF PQLHNKLKSF QDLCADYMKT IQQTMQEKIP LIREGEEEEE
     ESLEKFLDEQ ENSPFSKKNL NMWLDNLDRE INVIASCLDI MKGIKIIPEK SDLDREVLSV
     ENALCFVFTS IEMSDAYMDQ MASYFKETPN FVTLPAKDQW FFSDEVLENI KEKANMISET
     AKGLRSSSRF HFLVAALPNE EYTGATIYHY RKGVLKTKDF AKPAIHRVRN VTDKQDLMWY
     SCDLTLDPET VNGYLTLSAG DKKATSGSWE KYPKTEKRFD WYPQVLCREG LRGCHYFEVK
     WSSESTKDLG IGLAYESNPR RGNRKSTGFG YNNVSWFFGV NDDELRAWHD FSKIWKSSLP
     TGCNKIGVYL DWPAGTLSFY QVSSDTLTHL FTFENRFTEA LYPGFYIYDK SNFAMFCPV
//