ID A0A3Q2CZD5_CYPVA Unreviewed; 742 AA.
AC A0A3Q2CZD5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000011287.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000011287.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_015249912.1; XM_015394426.1.
DR AlphaFoldDB; A0A3Q2CZD5; -.
DR Ensembl; ENSCVAT00000018215.1; ENSCVAP00000011287.1; ENSCVAG00000013573.1.
DR GeneID; 107097299; -.
DR CTD; 57144; -.
DR GeneTree; ENSGT00940000158656; -.
DR OMA; KSHPQGH; -.
DR OrthoDB; 460351at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:InterPro.
DR CDD; cd01093; CRIB_PAK_like; 1.
DR CDD; cd06658; STKc_PAK5; 1.
DR Gene3D; 3.90.810.10; CRIB domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR000095; CRIB_dom.
DR InterPro; IPR036936; CRIB_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR033923; PAK_BD.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR028754; STKc_PAK5.
DR PANTHER; PTHR48015:SF27; SERINE/THREONINE-PROTEIN KINASE PAK 5; 1.
DR PANTHER; PTHR48015; SERINE/THREONINE-PROTEIN KINASE TAO; 1.
DR Pfam; PF00786; PBD; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00285; PBD; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50108; CRIB; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 11..24
FT /note="CRIB"
FT /evidence="ECO:0000259|PROSITE:PS50108"
FT DOMAIN 472..723
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 96..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 229..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 284..307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..420
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 502
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 742 AA; 83060 MW; D2C815491800C285 CRC64;
MFGKKKKRLE ISAPSNFEHR VHTGFDPREQ KFTGLPQQWQ SLLADTANRP KPMVDPSYIT
PIQLAPMKTI VRGNRPPKDA SINGLLEEFD NISVTRSNSL RKESPPGVQQ AGTSSKPLGS
GHLAALEENG FNHYYSRYSC DLDTSSREFS LEHGKPSFSI DGEWAVGRHY RFTKQNGHSH
PIRSSFYPDA MPQKSDYGKL PPDYHTYLES KGRSADEVAS TVGSGVGSSG YYRASVGGSS
SQDYRDTSVG TPSRASLHSE QINYPDSEWS YGGLRDDYDK RPKSSYVTQT SPTPAIRQRS
RSGSGLQEQN VPYAASGALR NAPQAHPYSS YTYPRLSESL ANSQTIGKGD YERSSRDESP
QVAGGDTYLR GPLKLPQSQI KPPGYPPAHL PYPPMFHHYK PSPYHHPPSQ PSPPYTPQGA
YSQPSSPYIP PGAYPPPSWG SSSDTQPSRV SHEQFRAALQ LVVNPGDPRE YLDNFIKIGE
GSTGIVCIAS EKHSGKQVAV KKMDLRKQQR RELLFNEVVI MRDYHHENVV DMYNSYLVGD
ELWVVMEFLE GGALTDIVTH TRMNEEQIAT VCLSVLRALS YLHTQGVIHR DIKSDSILLT
SDGRIKLSDF GFCAQVSKEV PKRKSLVGTP YWMAPEVISR IPYGTEVDIW SLGIMVIEMV
DGEPPYFNEP PLQAMRRIRD NLPPRLKESH KVSTVLRSFL DMMLVREPSQ RATAQELIQH
PFLKLSGPPS CIVPLMRHYR HR
//