ID A0A3Q2D0I9_CYPVA Unreviewed; 1933 AA.
AC A0A3Q2D0I9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Myosin heavy chain, fast skeletal muscle-like {ECO:0000313|Ensembl:ENSCVAP00000011813.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000011813.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000011813.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2).
CC {ECO:0000256|ARBA:ARBA00038612}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 28743.ENSCVAP00000011813; -.
DR Ensembl; ENSCVAT00000018896.1; ENSCVAP00000011813.1; ENSCVAG00000014231.1.
DR GeneTree; ENSGT00940000162888; -.
DR OMA; TKNEEHM; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 4.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.10.250.2420; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF44; MYOSIN-4; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 33..82
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 86..779
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 656..678
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1879..1933
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 843..1277
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 179..186
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1933 AA; 221743 MW; C2F8E79363F58304 CRC64;
MSSDPEMECF GPAAVYLRKP ERERIEAQNT PFDAKTAYFV TEQAEMYLKG KLVKKEGGKA
TVEVQGGKTL TVKEDEIFPM NPPKFDKIED MAMMTHLSEP AVLYNLKERY AAWMIYTYSG
LFCVTVNPYK WLPVYDAVVV AGYRGKKRIE APPHIFSISD NAYQFMLQDR ENQSILITGE
SGAGKTVNTK RVIQYFATIA VASSGKKAEP IPGKMQGSLE DQIIAANPLL EAYGNAKTVR
NDNSSRFGKF IRIHFGTSGK LASADIETYL LEKSRVTFQL SAERSYHIFY QLTTGHKPEL
IEALLITTNP YDFPMISQGE ITVKSINDVE EFMATDTAID ILGFTAEEKV SIYKLTGAVM
HHGNMKFKQK QREEQAEPDG TEVADKIAYL MGLNSADMLK ALCYPRVKVG NEMVVKGQTV
PQVHNAVSAL CKSVYEKMFL WMVVRINEML DTKQPRSFFI GVLDIAGFEI FDFNSLEQLC
INFTNEKLQQ FFNHHMFVLE QEEYKKEGIE WEFIDFGMDL AACIELIEKP LGIFSILEEE
CIVPKATDMT FKSKLYDQHV GKSAPFQKPK PAKGKAEAHF SLVHYAGTVD YNVNGWLDKN
KDPLNDSVVQ LYQKSANKLL AHLYASHAGT DGGKKGGGKK KGGSFQTVSA LFRENLGKLM
TNLRSTHPHF VRCLIPNESK TPGLMENFLV IHQLRCNGVL EGIRICRKGF PSRILYGDFK
QRYKVLNASV IPEGQFIDNK KASEKLLGSI NIDHTQYRFG HTKVFFKAGL LGTLEEMRDE
KLVQLVTMTQ ALCRGYVMRK EFVKMMERRE SIFTIQYNIR AFMNVKTWPW MKLYFKIKPL
LKSAETEKEM AQMKEDFEKT KEELAKALAK KKELEEKMVS LLQEKNDLQL QVQSEGETLA
DAEERCEQLI KAKIQLEAKV KETSERLEDE EEINAELTAK KRKLEDECSE LKKDIDDLEL
TLAKVEKEKH ATENKVKNLV EEMASQDETI AKLTKEKKAL QEAHQQILDD LQAEEDKVNT
LTKAKTKLEQ QVDDLEGSLE QEKKLRMDLE RAKRKLEGDL KLAQETIMDL ENDKQQSDEK
IKKRDFEISQ LLGKIEDEQT IGVQLNKKIK ELQARIEELE EEIEAERAAR AKVEKQRSDL
SRELEEISER LEEAGGATSV QIEMNKKREA EFQKLRRDLE EATLQHEATA AALRKKQADS
VAELGEQIDN LQRVKQKLEK EKSEYKMEID DLSSNMEATA KAKANMEKMC RSLEDQLSEL
KTKNDEHIRQ LNDTNSHKAR LVSENGEISR QLEEKESLVS QLTRGKQAFM HQIEELKRHL
EEEIKAKNAL AHAVQSARHD CDLLREQYEE EQEAKGELQR AMSKANSEVA QWRAKYETDA
IQRTEELEEA KKKLAQRLQD AEESIEAVNA KCGSLEKTKQ RLQGEVEDLM IDVERANALA
ANLDKKQRNF DKVLAEWKQK YEESQAELEG AQKEARALNT EMFKMKNSYE EALDHLETLK
RENKNLQQEI SDLTEHISES GKTIHELEKG KKMAENEKAE IQTALEEAEA TLEHEESKIL
RVQLELTQVK GEIDRKIAEK DEEIEQIKRN SQRVMESMQS TLDAEVRSRN DALRVKKKME
GDLNEMEIQL SHANRQAAEA QKQLRNVQGQ LKDAQLHLDE AVRAQDDMRE QVAIVERRNS
LMVAEIEELR AALEQTERSR KVAEQELVDA SERVTLLHSQ NTSLINTKKK LEADFVQIQG
EVEDAIQEAR NAEEKAKKAI TDAAMMAEEL KKEQDTSSHL ERMKKNLEVT VKDLQHRLEE
AENLAMKGGK KQLQKLEARV RELEGEVEAE QRRGAEAIKG VRKYERRVKE LTYQTEEDKK
NITRLQDLVD KLQLKVKSYK RQSEEAEEQA NTHLSRYRKV QHELEEAQER ADIAESQVNK
LRAKSREMTR VQS
//