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Database: UniProt
Entry: A0A3Q2D0N7_CYPVA
LinkDB: A0A3Q2D0N7_CYPVA
Original site: A0A3Q2D0N7_CYPVA 
ID   A0A3Q2D0N7_CYPVA        Unreviewed;       837 AA.
AC   A0A3Q2D0N7;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN   Name=CLCN3 {ECO:0000313|Ensembl:ENSCVAP00000011734.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000011734.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000011734.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Early
CC       endosome membrane {ECO:0000256|ARBA:ARBA00004520}; Multi-pass membrane
CC       protein {ECO:0000256|ARBA:ARBA00004520}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004107}. Lysosome membrane
CC       {ECO:0000256|ARBA:ARBA00004155}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004155}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU361221}.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family. ClC-
CC       3/CLCN3 subfamily. {ECO:0000256|ARBA:ARBA00008934}.
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DR   RefSeq; XP_015230958.1; XM_015375472.1.
DR   AlphaFoldDB; A0A3Q2D0N7; -.
DR   Ensembl; ENSCVAT00000018796.1; ENSCVAP00000011734.1; ENSCVAG00000014141.1.
DR   GeneID; 107085245; -.
DR   CTD; 1182; -.
DR   GeneTree; ENSGT00940000153763; -.
DR   OrthoDB; 150430at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR   CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR   CDD; cd03684; ClC_3_like; 1.
DR   Gene3D; 3.90.1280.20; -; 2.
DR   Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR   InterPro; IPR000644; CBS_dom.
DR   InterPro; IPR046342; CBS_dom_sf.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002245; Cl_channel-3.
DR   PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR   PANTHER; PTHR45711:SF8; H(+)/CL(-) EXCHANGE TRANSPORTER 3; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01114; CLCHANNEL3.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF54631; CBS-domain pair; 1.
DR   SUPFAM; SSF81340; Clc chloride channel; 1.
DR   PROSITE; PS51371; CBS; 2.
PE   3: Inferred from homology;
KW   CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW   ProRule:PRU00703};
KW   Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Ion transport {ECO:0000256|RuleBase:RU361221};
KW   Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361221};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        172..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        214..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        242..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        271..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        344..366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        386..405
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        457..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        490..511
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   TRANSMEM        531..556
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361221"
FT   DOMAIN          616..682
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   DOMAIN          713..770
FT                   /note="CBS"
FT                   /evidence="ECO:0000259|PROSITE:PS51371"
FT   REGION          811..837
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   837 AA;  93453 MW;  1497F26D2A66B0BE CRC64;
     MSELDLRHQE GSNYAMSNGG GAASSSTHLL DFLEEPIPGV GTYDDFHTID WVREKCKDRE
     RHRKINSKKK ESAWEFTKSL YDAWSGWLVV TLTGLASGAL AGLIDIAADW MNDLKEGVCL
     SAMWFNHEQC CWTSNETTFD ERDKCTQWKS WAELILGQAE GPGSYIMNYF MYIYWALSFA
     FLAVCLVKVF APYACGSGIP EIKTILSGFI IRGYLGKWTL MIKTITLVLA VASGLSLGKE
     GPLVHVACCC GNIFSYLFPK YSKNEAKKRE VLSAASAAGV SVAFGAPIGG VLFSLEEVSY
     YFPLKTLWRS FFAALVAAFV LRSINPFGNS RLVLFYVEYH TPWYLFELIP FILLGVFGGL
     WGAFFIRTNI AWCRRRKSTR FGKYPVLEVI LVATITAVVA FPNPYTRQNT SELIKELFTD
     CGPLETSALC KYRSEMNGST AYTDNPNQPA GPGVYSAMWQ LCLALIFKII MTIFTFGLKV
     PSGLFIPSMA IGAIAGRIVG IAMEQLAYYH HDWFLFKEWC EVGADCITPG LYAMVGAAAC
     LGGVTRMTVS LVVIVFELTG GLEYIVPLMA AIMTSKWVGD AFGREGIYEA HIRLNGYPFL
     DAKEEFTHTT LARDVMRPRS SDPPLAVLTQ DDLTVEELQG IINETSYNGF PVIVSKESQR
     LVGFALRRDI TIAIENARRR QEGIMLNSRV YFTQHAPTLP ADSPRPLKLR SILDMSPFTV
     TDHTPMEIVV DIFRKLGLRQ CLVTHNGNVL GIITKKNILE HLEELKQHTE PLAASWYRHK
     KRYPSSHGSN GKPRSRVHHV QLIRSFQDGW GGGGGCNEEG EQEEEDEEVC LLKGTDL
//
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