ID A0A3Q2D1U5_CYPVA Unreviewed; 1294 AA.
AC A0A3Q2D1U5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Crumbs cell polarity complex component 1 {ECO:0000313|Ensembl:ENSCVAP00000012318.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000012318.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000012318.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR STRING; 28743.ENSCVAP00000012318; -.
DR Ensembl; ENSCVAT00000030279.1; ENSCVAP00000012318.1; ENSCVAG00000014904.1.
DR GeneTree; ENSGT00940000155152; -.
DR OMA; NCTEFQG; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 10.
DR CDD; cd00110; LamG; 3.
DR Gene3D; 2.60.120.200; -; 3.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24049; CRUMBS FAMILY MEMBER; 1.
DR PANTHER; PTHR24049:SF1; PROTEIN CRUMBS HOMOLOG 1; 1.
DR Pfam; PF00008; EGF; 9.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 3.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 13.
DR SMART; SM00179; EGF_CA; 12.
DR SMART; SM00282; LamG; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 10.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS00022; EGF_1; 10.
DR PROSITE; PS01186; EGF_2; 7.
DR PROSITE; PS50026; EGF_3; 13.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1232..1258
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 12..47
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 78..114
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 116..153
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 155..191
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 246..288
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 290..330
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 332..518
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 520..556
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 562..734
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 767..803
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 831..1028
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1030..1066
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1068..1103
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1105..1141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1144..1182
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1184..1220
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 104..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 181..190
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 320..329
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 546..555
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 793..802
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1056..1065
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1072..1082
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1093..1102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1131..1140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1172..1181
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1210..1219
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1294 AA; 141862 MW; 8B0AC5114B008143 CRC64;
MKGTSPEKLP QTVDPCSPNP CQNQALCKNR GDGYSCFCVP GFQGLCTFFT LSLCSWAHLA
HDISVALMLF TGTTCEIQLH QCQSQPCLHG GICVEDDVGS ICLCYVGFQG ERCEINTDEC
QEHPCQNGGL CIDGVNEYSC DCSHTAFTGA LCETPLSPCY SDPCFNNAIC KDNQGNYTCE
CWPGFEGRNC EIDANECSCS PCLNGGSCIR GSWPALYGSK PLLPKDYEHS FPSFLSLLTG
SHCQEVINHC ESTPCQNGGR CESLVGGFLC HCLNQSPDGV LYGGVNCDVK LVGCEGHECQ
NQGFCSPFLQ DGTHGYTCSC TPGYTGPLCN TPTTFSFERR GYLLLHNPLL NADLTCNITL
SFKTVLPSAL LFQRSIRGLL LRLELEGGHL GLTLRREESA GSGAESHQAL ELQRNITDGE
WHTVEAVLTN EDLSLRLVGD AGNCGDQPCY KVAPVPSSLI GLDTSPQNTF IGGALNDPSG
SSSFPAFIGC MRDVFVDWQL VVPEEWLSDS AVNVSPGCSH RDRCLDKPCQ NRGQCVNLWQ
SYHCQCARPY EGHDCEEEHV TARFGHEDFH SYAAFTITED LGQNLSVSLF LRTRRQNGLL
LVLTNSSSPY LHMWLDAGRV TVRIHNSESL KARRAIHDGE VHFLNIEVLD GHLSLHVAGE
NQGEIEVRTV DVQAGDRAFV GGLLEKRTTS EFGGFFKGCI QDLRISDRRL QFFGLDAAVG
SYPLDLMEKV IAGCSGDNTC TVRKHRFKRT DVWIRFCVFR SRIDTSLIKK LLINPCLNGG
ICFSEWDDFT CTCPSSTAGR RCEEVKWCEL SPCPAASECK MLQQGYECYS NATFLNDSTV
MVYQGNGRIT RNITSLSFTI RTRKRNAAIL HAEKGSSFIT VSVQDGLLFM ELQSSMNKED
KEERENGLST VSLSSKRSIS DGEWHTAHLF MTAPWAQSSR WTLVLDEEIE EASISRSQGR
NLNFLREGVD IYLGGLAPNA GWSLAGCLGT VELGGIALPY FRSQEVNLPR LQEEQFVQSS
AEPALPGCRG ASVCEPSPCL NNGQCHDLFN TYNCTCAEGW AGRRCDVLIN TCASSPCVHG
NCTVNGLTYE CTCEFGYTGV DCEEEVDVCE NHLCANGATC LHGPEKYACL CPENYTGPLC
RSLPVSVCGD EHRNYTCFNG GNCTDRELSC DCPAGFIGHR CEQEVDECES NPCLNGGYCR
NLINKFVCVC DMSFAGDVCQ TDLTSEGLTS DLLLSVSLAS VILLLVLILT SIGLVAALNR
RATHGTYSPS RQEKDGSRVE MWSITQPPLM ERLI
//
