ID A0A3Q2D2N5_CYPVA Unreviewed; 538 AA.
AC A0A3Q2D2N5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rap guanine nucleotide exchange factor like 1 {ECO:0000313|Ensembl:ENSCVAP00000012547.1};
GN Name=RAPGEFL1 {ECO:0000313|Ensembl:ENSCVAP00000012547.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000012547.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000012547.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2D2N5; -.
DR Ensembl; ENSCVAT00000019826.1; ENSCVAP00000012547.1; ENSCVAG00000014988.1.
DR GeneTree; ENSGT00940000160144; -.
DR OMA; LQPNEDC; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF230; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR-LIKE 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 322..536
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 538 AA; 61739 MW; 6A183AF11E481FC7 CRC64;
MPAGMKPLEK FLKKQTTALT RAGGFGGVGD KASGTGASRR RASLSRVVPF FRETSPESGH
VREVFTLLDD FMLTHPIFLT ADRLQQVLLQ FTLEADGGGG ERRDGEVQMS AAERKQAVLN
MAFRYLDTYR ELLQEEGERS NSFPKELYSC AVKELTRYPE LVEDVLKLQR WTEILHCSDE
EKESRKKQVR PLFRHFRRID ACLQPREAFR GSDEFCRVYT PDHSYVTIRS RLSCRVGEIL
ALVKEKLQYS EDQPVLPGNL ILVAVTSSGK AVFRPSDEAV FTTLGVNTHL FACEPSELDS
LQLPLPEEIH WTPGDSKLHD MSAEEVANQL VVFDWELFSC VHEVEFICYV FHGEQSRWRP
LNLELVLQRC SEVQHWVATE ILQCQSLPKR IQLLRKFIKI AACKQQQDLL SFLAVVLGLD
NPAVSRLRLT WEGLPGKFRK QFQQFESLAL QDPSRNHKSY RDLMTSLRPP LIPFTPLLLK
HKVAEMVRTI RRFRSSQLVD TETSPSHLQT KAYVRQLQVI DNQNLLFDMS CKLEPKDT
//
