ID A0A3Q2D3K1_CYPVA Unreviewed; 1107 AA.
AC A0A3Q2D3K1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Integrin subunit alpha 7 {ECO:0000313|Ensembl:ENSCVAP00000013028.1};
GN Name=ITGA7 {ECO:0000313|Ensembl:ENSCVAP00000013028.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000013028.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000013028.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_015258269.1; XM_015402783.1.
DR AlphaFoldDB; A0A3Q2D3K1; -.
DR STRING; 28743.ENSCVAP00000013028; -.
DR Ensembl; ENSCVAT00000020441.1; ENSCVAP00000013028.1; ENSCVAG00000015509.1.
DR GeneID; 107103206; -.
DR CTD; 3679; -.
DR GeneTree; ENSGT00940000159891; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF90; INTEGRIN ALPHA-7; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 1031..1055
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 41..107
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 303..364
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 365..421
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 425..484
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 469..631
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 634..795
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 801..1021
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1107 AA; 123108 MW; 959DA635E58A7D7B CRC64;
MASLMGHGDL AFLSSVSPHP SMFLLWTLSS FLGQVYCFNL DTTHTLHKLG DRGTFFGFSV
ALHQQLTPEP QSWILVGAPQ AAGQGQLRGS RPGALFRCPI TPEEYDCERV DIDGDINLDR
ENKDNQWLGV SVKSQGIGGK VVVCAHLYEL RQRVRQPSET RDPIGRCYVL SDDLTKRDEL
DGGEWKFCQG RPQGHEQFGF CQQGLSVNFT PDRKYILFGA PGTYNWKGLL FMASAVEDTL
VHKTLEPSTP FQDVAHHSYL GFSVDSAKGI MNQEELTFVT GAPRANHTGA VVLLKTDNVH
RLVPQHIFWG EELASSFGYS VATADLNNDG WTDVIVGAPN FFDRKAEIGG AVYVYLNPFG
HWTDQARPIR LNGTYDSMFG MTVSNIGDLD QDGYGDIAVG APFDGDGKVF IYRGLETGIE
TKPAQVLDGH DFDVKRFGYS ISGGLDIDEN HYPDVVVGSL NDSVVLFRSR PVIQVTRDVT
IDPQYIDLEQ KNCKGREGFC VEVQACFMFT AHPHHYSPHI TLVVQFEADM ERRKLGLPHR
VDFLGRSSLD PEYTQTEEVE LHRQRHTACT TAIFQLHESI RDKLRPISLA ITHTIKPVPP
RRHSAKKAQK LPPVLNISPS NTLHTEVNFL RQGCGSDKIC QSNLKLSYQF GTKPLSSDFF
TPLPKDDDGV QVFSLSDQRL VVLEITVTNM PSDPLNPEED GDDAHASQLF ISLPDALPYA
GSRVPPQMIC QANQNGSLVE CDLGNPVKRN AKLIFTINLS TSNITTETTE LTADLQLATI
SEQLDLDPVT AYAKVVIELP LSVSGLARPH QLFFSGMVKG ESAMTSLEDI GSPVDIELVI
SNPGKALQTL GSAFLNIMWP SELANGKWLL YPASLKFEDQ PETYCSPSEA INPLKLSSSA
ADQVVGRSRR SHPEEKYLVV TKDSDERTTP AVAASERRKS IKLDCLLGSA RCVLFQCPLH
SFTGQTVLKI HARLWKSSFI EDFPTVSALE LLIRANITVK SSIKHLVLRD ASVQIPVMIY
PELGLADQYL IPWWIILVAI LAGILLLTLL VCLLWKCGFF RRATYKDKLP QYHAVKIPRE
LRPQFQTEKS ESVQKKEWAT HWSDGTL
//
