ID A0A3Q2D3P0_CYPVA Unreviewed; 1015 AA.
AC A0A3Q2D3P0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Signal peptide, CUB and EGF-like domain-containing protein 3 {ECO:0000313|Ensembl:ENSCVAP00000013073.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000013073.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000013073.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR RefSeq; XP_015246172.1; XM_015390686.1.
DR AlphaFoldDB; A0A3Q2D3P0; -.
DR STRING; 28743.ENSCVAP00000013073; -.
DR Ensembl; ENSCVAT00000020491.1; ENSCVAP00000013073.1; ENSCVAG00000015591.1.
DR GeneID; 107094829; -.
DR KEGG; cvg:107094829; -.
DR CTD; 222663; -.
DR GeneTree; ENSGT00940000153185; -.
DR OrthoDB; 5477406at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0048513; P:animal organ development; IEA:UniProt.
DR CDD; cd00041; CUB; 1.
DR CDD; cd00054; EGF_CA; 2.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 3.
DR InterPro; IPR026823; cEGF.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR24046; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24046:SF2; SIGNAL PEPTIDE, CUB AND EGF-LIKE DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF12662; cEGF; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 3.
DR Pfam; PF14670; FXa_inhibition; 4.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM01411; Ephrin_rec_like; 3.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 6.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS01186; EGF_2; 5.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1015
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018569790"
FT DOMAIN 34..74
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 305..345
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 346..384
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 385..425
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 825..937
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 350..360
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1015 AA; 111720 MW; 11F3BE6BE556BD03 CRC64;
MYLHALIRAS LGFVGFLLVA FVQHSASGSK TTQDVDECAE ALDNCSIDAI CQNTPKSYKC
ICKSGYKGDG KHCEDVDECA TEYNGGCVHE CINIPGNYRC TCYDGFRLAH DGHNCLDVDE
CSEGNGGCQQ ICVNMMGSYE CRCREGFLLS DNQHTCIQRP KVQPEGTKEG PTCMDKNHGC
AHICREAQKG GISCECRPGF QLTRNMKDCK LTCNYGNGGC QHICEETDHG PKCSCHMKFV
LHSDGKTCVG ERSVQSKAAP QLFPNETCAV NNGGCDSTCH DSVTGVRCSC PVGFTLQPDR
KTCKDIDECR LNNGGCDHVC RNTVGSFECS CKKGYKLLTN ERTCQDIDEC SFDRACDHFC
VNSAGSFQCI CNKGYVLYGL AHCGDIDECS INRGGCKYGC INTLGSYECT CPPGYKLHWN
KKDCIELVKC PPGLVAPKAT LTCSRTGKKE SCSLTCASKA YYLAGANNSY SVSCGIPILT
GKSPARINSS IIQGCVETLA PPVKQKTSFK IKNAKCHLHP KLTGRTEDRG RMLGPGGGQP
CSNCQVTFVN LTCDSSKKAK GRHARNPSNK GITRITLELE AEVKPGDTTG SCNLSCLRQR
MELQVKTYIK ALKKSINQER FLIRVAGLEY EVAQKLAQAA PIQDHCAPGW ERVNGRCVIC
LPGSYYHGGQ ERCVQCPPGT FQEKEGQLAC DLCPGSDGHG PVGARNISSC AGQCPTGYFS
SDGFKPCQPC PQGTYQSDLG RTLCFPCGGG LSTKREGASS FHDCEVKVQC SPGHYYNTTV
HRCIRCPVGT YQTEFRQNYC ITCPGNTTTD FDGATSVSQC KNRQCGGEMG ELMGYIESPN
YPGNYPANVE CIWNINPPSK RKILIVVPEI FLPSEDECGD VLVMRKNWSA TSITTYETCQ
TYERPIAFTA RSRRLWINFK SNEANSARGF QIPYVTYDED YEQLVEDIVR DGRLYASENH
QEILKDKKLI KTLFDVLANP NHYFRYTPRE SNEMLPRSFI RLISSKVSAF LRPYK
//
