ID A0A3Q2D471_CYPVA Unreviewed; 1999 AA.
AC A0A3Q2D471;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Disks large homolog 5-like {ECO:0000313|Ensembl:ENSCVAP00000013268.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000013268.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000013268.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_015245327.1; XM_015389841.1.
DR Ensembl; ENSCVAT00000020743.1; ENSCVAP00000013268.1; ENSCVAG00000000872.1.
DR GeneID; 107094188; -.
DR CTD; 569065; -.
DR GeneTree; ENSGT00940000155303; -.
DR OrthoDB; 2877432at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd01671; CARD; 1.
DR CDD; cd00992; PDZ_signaling; 4.
DR CDD; cd11860; SH3_DLG5; 1.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR006907; DLG5_N.
DR InterPro; IPR035537; DLG5_SH3.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46360; DISKS LARGE HOMOLOG 5; 1.
DR PANTHER; PTHR46360:SF1; DISKS LARGE HOMOLOG 5; 1.
DR Pfam; PF16610; dbPDZ_assoc; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF04822; Takusan; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..92
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 678..768
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 763..854
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1424..1503
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1584..1664
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1675..1743
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1855..1985
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 88..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1035..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1507..1580
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 126..461
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 490..654
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 93..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1051..1081
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1152..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1358..1391
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1507..1574
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1999 AA; 224512 MW; C48371413EC02776 CRC64;
MEPKHKELLD QCHQNLLESI TDADRVIELL IVSGTLSQLD RFELEQNCAS SAEKVDHLLK
MLMNKESDHF LDLCVALEKA YPDLHSALFS NNGGGPVDHS TGSPVNGETS SPPPAVNDNR
HASENLDTIL LQLRQVTRER DELRKRLALA SPGTTFDDCR PNPKASHDYE RLKSQCMRAM
ADLQSLQNQH TKTLKRCEEA VKEADFYHML HSRVLGDQTQ LKEEMETVRR DNAQLVREHN
HLKQNCEELK RLHSQDQQEL SDLRQQQQEV MREKGSSEVL NKLYDTAMDK LEGVKKDYDA
LSKRFGEKVA NHNTDLSRLE QAEEENRRLQ KQMDALLKQR DSAMHYQQQF STSMRRFDSV
QQELNKSSAQ NKELQREMER LQSEVTRYKN LQLKAAKDCE KYKEERDSVF NEYRLIMSER
DQVIKELDKL QTELEAAEAR LKNTSSERVV ASEELEALRQ ELNSSLVDRD RAICERNELL
EKYCHEVKDK AEAQKELSQA CKDIEMVREE RDVARKERTE AIIQRDQLLR EYYQARQKQD
SATLDMERAN KEIEMLRKQY EAMSQELKEA TQEAEVAKCR RDWAFQERDK IVAERESIRT
LCDNLRRERD RAVSDLADAL RNLDDMRKQK NDALRELKEL KEKMESQLEK EARFCQLMAH
SSHDSAIDTD SLEWETEVVE FEKDREDMDL KALGFDIAEG VNDPYLPGDC GIFVTRVDKG
SVADGRLRVN DWLLKINDID LSNKDRKQVV KAVLNGGGLI NMVVRRRKSL GGRLVTPVHI
NLMGHKDSGI GLESGVFVTA IAQGSPAARE GSLTAGDRLI AINGIALDNK SVTECEALLR
SCRDSLSLSL MKFFPHSTSG QNIFESLRDS SEKTNGRMLL SEIHSRNSRN LKHNSSTQTD
IFCPDVGSAS SSSISGDRRK LRGDDEMYGD VSKPFSSVSL HATSLRPLAD LGTGRYGPSA
FQECCSYTKG PSSLPFEPIS HSECINMETA LEKKHSGGTW PKMMVGGMSV VPDSSGPITA
AAQLSIYKSP KQRKSIFDPD TFKRPETPSS KLEYLTANQM SAVSSHSPQS SKTESLSSSS
TPTPTPPTPP TRSDSFKFKH KHQSSSASDC TITSDGKGEA SISMAAGEGR ERNERERDRN
GNHYFLEGKV LTSRKSCDED IGRTRGEEPE VKRPRPKSAP ALRRRTPKTI THPIYQSYSN
DDHSPDSRDV LHSSPSPSNR HSVGLVPAVY NGSLPPNSAH RGLSPCPAVT AVMRNPVYTV
RSHRVHTSNC PSVASQICHQ HTHTSPQHQG RLSLDLSQQK RTSDYSETAS SRSSRASHGT
NSLPSGTRLG SSSNVQYRTE RIKIPSTPRY PRSMLGSDRG SLSHSECSSP SLITPPQSPL
NLETSSFVSS QSQGSISTLP RISVSPVPIG ERRKDRPYLE EPRNVIVHKG AEPLGISIVS
GENGGIFVSK VTGGSIAHQA GLEYGDQLLE YNGINLRNAT EQQARLIIGQ QCDTITIMAQ
YNPHMYQLGN HSRSSSRLEP VSTQLTPQGS GTATPDSHSA IDTLSEQDEG TLTPSSKQTT
PTTSPNSCVR MPSESNRRVS EPRLVTVHRP GVEVGVTLCG GNLRGIYIES VDEDSPARGP
DGLLPGDLIL EYNSVNMKNK XAEEVYVEML KPAETVTLKV QHQPDDFSSV KDVPGDGFYI
RALYDRVGEA EGDLSFKKDD ILYVDESLPK GSFGTWMAWQ LDENAQQIQR GQIPSKYMID
QEFYRRHSVT EMKEDSSKTI SAAARRSFFR RKQKHKRSSS KDSKEMVPLD TISTDSIPFL
DDCVSLAYQR VQKVECTSPR PVLVLGPLSD PVKEMLVKES PGKFCRCLLE VMKASQQAIE
RGVKDCLFID YKRRSGHFDV TTVASIKEIT DKGCHCLLDI APHAIERLHS VHIYPIVVFI
RYKNAKQIKE QKDPIFLRDK VSQKHSKEQF ESAQKIEQEY SKFFTGIVQG GNLPYICTQI
TTIVDQEQSK VLWTPLGSP
//
