ID   A0A3Q2D4B4_CYPVA        Unreviewed;       872 AA.
AC   A0A3Q2D4B4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=GTPase activating Rap/RanGAP domain like 3 {ECO:0000313|Ensembl:ENSCVAP00000013406.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000013406.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000013406.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2D4B4; -.
DR   STRING; 28743.ENSCVAP00000013406; -.
DR   Ensembl; ENSCVAT00000020939.1; ENSCVAP00000013406.1; ENSCVAG00000015980.1.
DR   GeneTree; ENSGT00940000159362; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   PANTHER; PTHR15711:SF62; GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3; 1.
DR   PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00036; CNH; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          22..238
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   DOMAIN          326..643
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          650..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          776..835
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..673
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        788..811
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   872 AA;  97437 MW;  07F29B896D0CE959 CRC64;
     MNMDRFEKGP REILNPEIQK DLLVLEEQEG SVNFKFGVLY AKDGQLTDDE MFSNETGSEN
     FDKFLNLLGD TITLQGWAGY RGGLDTKNDT TGLQSIYTVY QGHELMFHVS TMLPYSKENK
     QQVERKRHIG NDIVTIVFQE GDEVSSSFKP SMIRSHFTHI FALVRYNSQN DSYRLKIFSE
     ESVPLFGPPL PSPPVFTDHH EFRDFLLVKL INGEKATLET PTFAQKRQRT LDMLIRSLYQ
     DLMPDLHKVP FSPQNMLNRR SFSDVLPESP KSARKKEEAR QAEFVRIGQA LKLKTIVRGD
     APTSLVTTGL CRKEPWESQS FCSTFPYDIV CADSWGQSLL VATDTAGVMM LDGPDPVLPG
     AETPTLAPVQ VFDKTIAVKQ MHILEPQDLL ITRADKGKDA RLYVFRLGAI KRGLEERQLV
     RSKCDCRENK LEKTKGCHLY SINTHHGSEL RIVAAIRTKL LLITRKHPRF SAVASGTESP
     VEEFQYIREI CLCDPPVVMA LVDGPTGEND NMICVAYKHQ FDLINESTGD AYRLHHVDAN
     RVNFVAAIDV YEDGEAGLLL CYNYICYYKK VCPFNGSTPM IQSNTSDFHF SWNQMPNAIV
     CAFPYILAFT TDSIEIRLVV NGNLVYTAVV PELQLASSRS DIYFVSSAPV SSASNCSSRD
     TSSQSSPQTP TGYEMPVFPS PLGDDSIRIP YGTKLSLYMS KDAEGEATCK HIFKIPLCNL
     VGRSIERPLK SPLVNKVMTA PTPAMIAPAP LISATHSLSL SRMEIKEIAS RTRKELLGLT
     EEPSGKSDSG SVKQRKMSKK NTEEEPKARA LTSTNSDRLA SESTEAELDA QLHCSSALEV
     DPEMVVLQEE SPPLASAFTL STSFEDDVLD LK
//