ID A0A3Q2D4I6_CYPVA Unreviewed; 1069 AA.
AC A0A3Q2D4I6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Solute carrier family 12 member 5-like {ECO:0000313|Ensembl:ENSCVAP00000013491.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000013491.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000013491.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR AlphaFoldDB; A0A3Q2D4I6; -.
DR Ensembl; ENSCVAT00000021060.1; ENSCVAP00000013491.1; ENSCVAG00000016053.1.
DR GeneTree; ENSGT00940000165387; -.
DR OMA; MWRSFCD; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF54; SOLUTE CARRIER FAMILY 12 MEMBER 5; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 90..111
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..146
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 251..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..410
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 554..575
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 96..268
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 384..669
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 683..798
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 815..1069
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 66..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 937..953
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 118395 MW; 49B967E584ED8F8E CRC64;
MPQAPGDGHP RESSPFINSS ASLDIEKSQQ YDSKSMALFE EEIDTSPMVS SLLSSLANYS
NLPTGSKEHE EAENEEGARP SKKPVKAPQL GTLMGVYLPC IQNIFGVILF LRMTWMVGIG
GVFGSFIIVF MCCSTTMLTA ISMSAIATNG VVPAGGSYYM ISRSLGPEFG GAVGICFYLG
TTFAGAMYIL GCIEILLIYI VPQAAIFKIE GLEGPEAEIA LLNNMRVYGT LVLSFMAIVV
FVGVKYVNKL ALVFLACVIL SILAVYAGII KTALEPPVFP VCLLGNRTLL SKSYDVCAKV
IEIDNETITT QMWRSFCDSD SLNATCDEYF INNNVTEIQG IPGVNSGILA ENLFGNYLEK
GNFLEKRGIS STVDPDIPTT NSNRYVVADI TSFFTLLVGI YFPSVTGIMA GSNRSGDLRD
AQKSIPIGTI AAITTTSTVY MTCVVLFGAC IEGVVLRDKF GEGVNGNLVI GTLAWPSPWV
IVFGSFFSTC GAGLQSLTGA PRLLQAIARD GIIPFLRIFG HGKENGEPTW ALLLTASICE
IGIIIASLDS VAPILSMFFL MCYMFVNLAC ALQTLLRTPN WRPRFKFYHW ALSFLGMSLC
LSLMFICSWY YAIVAMGIAT CIYKYIEFCG AEKEWGDGIR GISLSAARFA LMRLEEGPPH
TKNWRPQILV LVSMDAEQNV EQPRLLSLTN QLKAGKGLTI VGTSVQGTFL DSYTEAQRAD
QSLRKLMETE KVKGFSQVVV SSNIRDGTSH LIQVGGLGGL KHNTVMVSWP QNWKQPECYQ
QFKNFIEVVR ETTIASLALL VPKNISSYPS NGERFTEGHI DMWWIVHDGG MLMLLPFLLR
QHKVWRKCKM RIFTVAQMDD NSIQMKKDLI TFLYHLRIDA AVEVVEMHDS DISAYTYEKT
LVMEQRSQIL KQMHLTKNEM EREIQSITDS SRGSIRRKKM STLQPQHSTE ESASLVENPE
DKVKASNICV SPSSVSKNKR KSYFSSCELK FSHFRNQTDV RRMHTAMRLN EVITKKSKEA
KLVLLNMPGP PKNRVGDENY MEFLEVLTEG LNRVLLVRGG GREVITIYS
//
