ID A0A3Q2D7T7_CYPVA Unreviewed; 1176 AA.
AC A0A3Q2D7T7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Thrombospondin-1-like {ECO:0000313|Ensembl:ENSCVAP00000014618.1};
GN Name=THBS1 {ECO:0000313|Ensembl:ENSCVAP00000014618.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000014618.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000014618.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the thrombospondin family.
CC {ECO:0000256|ARBA:ARBA00009456}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR AlphaFoldDB; A0A3Q2D7T7; -.
DR STRING; 28743.ENSCVAP00000014618; -.
DR Ensembl; ENSCVAT00000031191.1; ENSCVAP00000014618.1; ENSCVAG00000017402.1.
DR GeneTree; ENSGT00940000155832; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 6.20.200.20; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 3.
DR Gene3D; 4.10.1080.10; TSP type-3 repeat; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR003367; Thrombospondin_3-like_rpt.
DR InterPro; IPR017897; Thrombospondin_3_rpt.
DR InterPro; IPR008859; Thrombospondin_C.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR028974; TSP_type-3_rpt.
DR InterPro; IPR048287; TSPN-like_N.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR10199; THROMBOSPONDIN; 1.
DR PANTHER; PTHR10199:SF78; THROMBOSPONDIN-1; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF00090; TSP_1; 3.
DR Pfam; PF02412; TSP_3; 7.
DR Pfam; PF05735; TSP_C; 1.
DR Pfam; PF00093; VWC; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00209; TSP1; 3.
DR SMART; SM00210; TSPN; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF103647; TSP type-3 repeat; 3.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 3.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 2.
DR PROSITE; PS50092; TSP1; 3.
DR PROSITE; PS51234; TSP3; 4.
DR PROSITE; PS51236; TSP_CTER; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00634}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 321..378
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 553..593
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 652..696
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 733..768
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 792..827
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 889..924
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT REPEAT 925..960
FT /note="TSP type-3"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00634"
FT DOMAIN 964..1176
FT /note="TSP C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51236"
FT REGION 730..760
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 845..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 288..315
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 739..754
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..874
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1176 AA; 130963 MW; 0A87AB5B3464E881 CRC64;
MLWTCEGARV AGELKIFIYQ IISFFFFFFS NISNILELTY YSPAESREDN SVFDLFELIR
VPSKNHGVSL VKGDDPYSPA YRILNPDLIP PVPESAFRDL VDSVQAERGF LLLLNFKQFK
RTRGSLLTVE KRDGSGVVFE IISNGKANTL DIVYSTEKKQ QVVSIEEVDL ATGHWKNITL
FVQEDRAQLF AGCEEVNTAE MDAPIQNILT QGTPAGARLR VGKGAVKDKF MGVLQNVRFV
FGTTLDAILR NKGCQKGNVI YTRVDLNIYL QMVCGFSCED LISMFKELKG LGVVVKELST
ELRQLTNENK LIRTHMGIHS GICFHNGIKH NNKDEWTVDD CTECTCQNSA TVCRKISCPL
IPCANATVPD GECCPRCGTP SDYAEDGWSP WSEWTHCSVS CGRGIQQRGR SCDRINNVCE
GTSVQTRDCY LQECDKRFKQ DGNWSHWSPW SSCSVTCGAG VITRIRLCNS PTPQLGGRDC
VGEGRQTEKC KMSPCPINGN WGPWSPWGTC TLTCGGGVQT RKRLCNDPAP KHGGKECVGD
AIDKQMCNKK ACPIDGCLSN PCFSGAKCSS FPDGSWKCGK CPIGYTGNGI RCKDVDECKE
VPDACFEFNG VHRCENTEPG YNCLPCPPRY SGPQPFGKGV EQAAANKQVC TPQNPCLDGS
HDCNKNARCN YLGHFSDPMF RCECKPGYAG NGHICGEDTD LDGWPNADLV CVENATYHCK
KDNCPNLPNS GQEDYDKDGI GDACDDDDDN DGIPDDRDNC PFVYNPRQYD YDRDDVGDRC
DNCPYNSNPD QTDTDNNGEG DACAVDIDGD GILNEKDNCP YIYNVDQRDT DLDGVGDMCD
NCPLENNPDQ VDSDDDRVGD KCDSNQDIDE DGHQNNLDNC PYIPNANQAD HDKDGKGDAC
DHDDDNDGIP DDKDNCRLAF NPDQLDSDGD GRGDACKDDF DQDNVPDIYD VCPENFDISE
TDFRKFQMVP LDPKGTSQID PNWVVRHQGK ELVQTVNCDP GIAVGYHEFN SVDFSGTFFI
NTERDDDYAG FVFGYQSSSR FYVVMWKQIT QTYWSSKPTK AQGYSGLSIK VVNSTTGPGE
HLRNALWHTG NTAGQVRTLW HDPKNVGWKD FTAYRWHLIH RPRTGLIRVV MYEGKKIMAD
SGSIYDKTYA GGRLGLFVFS QEMVYFSDLK YECRGR
//
