ID   A0A3Q2D8J2_CYPVA        Unreviewed;       561 AA.
AC   A0A3Q2D8J2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Sorting nexin-27-like {ECO:0000313|Ensembl:ENSCVAP00000014918.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000014918.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000014918.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_015229217.1; XM_015373731.1.
DR   AlphaFoldDB; A0A3Q2D8J2; -.
DR   STRING; 28743.ENSCVAP00000014918; -.
DR   Ensembl; ENSCVAT00000022870.1; ENSCVAP00000014918.1; ENSCVAG00000017700.1.
DR   GeneID; 107084071; -.
DR   KEGG; cvg:107084071; -.
DR   CTD; 566205; -.
DR   GeneTree; ENSGT00950000183212; -.
DR   OrthoDB; 2874169at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:InterPro.
DR   GO; GO:0007409; P:axonogenesis; IEA:Ensembl.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProt.
DR   CDD; cd13338; FERM-like_C_SNX27; 1.
DR   CDD; cd01777; FERM_F1_SNX27; 1.
DR   CDD; cd00992; PDZ_signaling; 1.
DR   CDD; cd06886; PX_SNX27; 1.
DR   Gene3D; 1.20.80.60; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR037831; SNX17/27/31-like.
DR   InterPro; IPR037827; SNX27_FERM-like_dom.
DR   InterPro; IPR037833; SNX27_PX.
DR   InterPro; IPR037835; SNX27_RA.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR12431; SORTING NEXIN 17 AND 27; 1.
DR   PANTHER; PTHR12431:SF20; SORTING NEXIN FAMILY MEMBER 27; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00787; PX; 1.
DR   Pfam; PF00788; RA; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00312; PX; 1.
DR   SUPFAM; SSF50156; PDZ domain-like; 1.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50195; PX; 1.
DR   PROSITE; PS50200; RA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transport {ECO:0000256|ARBA:ARBA00022927}.
FT   DOMAIN          41..134
FT                   /note="PDZ"
FT                   /evidence="ECO:0000259|PROSITE:PS50106"
FT   DOMAIN          157..265
FT                   /note="PX"
FT                   /evidence="ECO:0000259|PROSITE:PS50195"
FT   DOMAIN          269..358
FT                   /note="Ras-associating"
FT                   /evidence="ECO:0000259|PROSITE:PS50200"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          528..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   561 AA;  63700 MW;  98ED12CB54C598A7 CRC64;
     MADVVGDESR PAHPAATRQH VPVVGSSAGQ NAATVTSGPR VVRIVKSESG YGFNVRGQVS
     EGGQLRSING ELYAPLQHVS AVLPGGAADR AGIAKGDRIL EVNGVNVEGA THKQVVDLIR
     AAEKELVLAV LSVPPQEADG LEGGEDIQPN YDYSDKQAVP ISIPTYKHVE QHSERFVVYN
     VYMSGRQLCS KRYREFAILH QNLKREFSNF NFPKLPGKWP FSLSEQQLDA RRRGLEEYLE
     RVCSVRVIGE SDIMQEFLSE SDENYNGVTD VELRIALPDK TTISVRVRKN STTDQVYQAL
     VLKVGMDSIM ASYFALFEVI NHSFVRKLAP NEFPHKLYVQ NYTSAVPGTC LALRKWLFSI
     QEEELLRDNP LALHYCFHQA LDDVKKGFIK TEDKSYQLQK LAEQRKMATY LSLLRTCEGY
     NEVVFPHCSC DSRRKGHVIT AISIHHFKLH ACTEDGTLEN QVIAFEWAEM QRWDTDEEGM
     AFCFEYARGE KKPRWVKIFT PYFNYMHECF ERVFCELKWR KQVEEEASDK DNKNCSNSEF
     LPPLETQQKG WRHLGGEIAT S
//