ID A0A3Q2D9G3_CYPVA Unreviewed; 690 AA.
AC A0A3Q2D9G3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Ligand of Numb protein X 2-like {ECO:0000313|Ensembl:ENSCVAP00000015352.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000015352.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000015352.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_015242588.1; XM_015387102.1.
DR RefSeq; XP_015242589.1; XM_015387103.1.
DR STRING; 28743.ENSCVAP00000029957; -.
DR Ensembl; ENSCVAT00000023418.1; ENSCVAP00000029957.1; ENSCVAG00000018132.1.
DR Ensembl; ENSCVAT00000031482.1; ENSCVAP00000015352.1; ENSCVAG00000018132.1.
DR GeneID; 107092561; -.
DR KEGG; cvg:107092561; -.
DR CTD; 564464; -.
DR GeneTree; ENSGT00940000164372; -.
DR OMA; DQRSDHH; -.
DR OrthoDB; 3028121at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:Ensembl.
DR GO; GO:0031017; P:exocrine pancreas development; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR CDD; cd16780; mRING-HC-C3HC3D_LNX2; 1.
DR CDD; cd00992; PDZ_signaling; 4.
DR Gene3D; 2.30.42.10; -; 4.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR19964:SF41; LIGAND OF NUMB-PROTEIN X-LIKE PROTEIN; 1.
DR PANTHER; PTHR19964; MULTIPLE PDZ DOMAIN PROTEIN; 1.
DR Pfam; PF00595; PDZ; 4.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM00228; PDZ; 4.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 4.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50106; PDZ; 4.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 48..86
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 213..284
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 334..417
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 465..550
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 600..686
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 149..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 149..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 311..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 425..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 690 AA; 76720 MW; A57C3319A6354C50 CRC64;
MAATETKAPS SAAGLSWARV CKECGQQHEG QETHLYEYQN EVDDELVCHI CLQPLLKPMD
TPCGHTYCYH CLSNFLKEQD FCPVDRQRLQ LNQCRPSSLL VRNLLDKLLV SCPHYADCQQ
KMQRCELQPH LHNRCPVFKR LREEAEKRKR PSWNEIKGRK GDGESSGDAK HSATLSRNPT
RDQSEPGLIN PAYEEIDDDN TPLRSSLVAE ANVVELFRDE PEEELGLRIV GGKDTPLGNI
VIQEIIRDSI ASRDGRLAPG DHILEVNDVS LASIPHSRAI AVLQHPSLLR LTVMQEKGFK
IRDQRSDHHA STFTASHSPH GNSPSSQNPG KVLHVMLTKT HRTEPLGIKL IRKSDESGVF
ILDLLPGGLA AKDGKLRNND KVLAINGHDL MHGTPESAAL IIQNSEKCVN FAVMRPAENP
EEGGSSSREG QHSRGVRRAP EPQYFRRQTT YLKDPPGGFS CQEKTVSLKK EPRTSLGITI
AGGRDCRSRL PVYITSVQPV GCLHRDGTIK RGDVLLSING VDLTQLTYTE AVSVLKAQTA
QSQVVLRVIQ TLSEGGEEDT ETGSRDDFDH VDDQREETRT WTPLWTHWLG LPSHMHWCRD
IVLQKTNNES WGFSIVGGYE ESHGQQPFFI KTIVPGTPAH FDGRLKCGDE IVAVNGATTV
GMNNSSLIPM LKLQKNKVTL TVVSWPGSLV
//
