ID A0A3Q2DA31_CYPVA Unreviewed; 1505 AA.
AC A0A3Q2DA31;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=P-type Cu(+) transporter {ECO:0000256|ARBA:ARBA00012517};
DE EC=7.2.2.8 {ECO:0000256|ARBA:ARBA00012517};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000015339.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000015339.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000256|ARBA:ARBA00004166}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004166}. Membrane
CC {ECO:0000256|RuleBase:RU362081}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|RuleBase:RU362081}.
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DR RefSeq; XP_015256544.1; XM_015401058.1.
DR STRING; 28743.ENSCVAP00000015339; -.
DR Ensembl; ENSCVAT00000023713.1; ENSCVAP00000015339.1; ENSCVAG00000018227.1.
DR GeneID; 107101958; -.
DR KEGG; cvg:107101958; -.
DR CTD; 538; -.
DR GeneTree; ENSGT00940000159568; -.
DR OrthoDB; 5480493at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005507; F:copper ion binding; IEA:InterPro.
DR GO; GO:0140581; F:P-type monovalent copper transporter activity; IEA:UniProtKB-EC.
DR CDD; cd00371; HMA; 6.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 6.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006122; HMA_Cu_ion-bd.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR NCBIfam; TIGR00003; copper ion binding protein; 5.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF29; COPPER-TRANSPORTING ATPASE 1; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 6.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00942; CUATPASEI.
DR SFLD; SFLDG00002; C1.7:_P-type_atpase_like; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 6.
DR SUPFAM; SSF81660; Metal cation-transporting ATPase, ATP-binding domain N; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01047; HMA_1; 5.
DR PROSITE; PS50846; HMA_2; 6.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362081};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Copper transport {ECO:0000256|ARBA:ARBA00022796};
KW Ion transport {ECO:0000256|ARBA:ARBA00022796};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}; Transport {ECO:0000256|ARBA:ARBA00022796}.
FT TRANSMEM 662..681
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 712..734
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 755..776
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 782..804
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 947..974
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 994..1014
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1365..1387
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 1393..1413
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 8..74
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 176..242
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 285..351
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 386..452
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 496..562
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
FT DOMAIN 572..638
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 1505 AA; 162825 MW; 14FFC33624752323 CRC64;
MTQKVSLSSV SLGVEGMTCG SCVQSIEQWI GSLHGVIQIK VSLEQKSATV IFDPSQQSPE
SLSEAIEDMG FESSVPESST ATPVSTDTQL IPTSGLTSAA QNQALEKLSE IPGVLDVQES
PPSMGLTVTF VPSLTSIQLL REVVAAASPQ EIPTPGSPSQ KDLNLSQSDA VGAEAAVLKF
SIEGMTCHSC TTTIEGKIGK LKGIKKIKVV LDSQEATVVY LPYLITIQTI IDQIGVAGFK
ATVKSKSRPL QLSHRDMERF IDSQKATLSS PSETSEETEV FIDTALTRLS VKGMHCRSCV
ANIQDNISML PGVSSVEVSL EKEEASICYD PLKVSVTQLQ QAIEALPPGN FKTEPLDFSH
TLSPVSTALH PRPAATQPCF TQPLVASVNI HIEGMTCNSC VQSIEGMMSQ RKGVRSAQVS
LTDHQGVFEY DPLLTTPEEL KEAVEDMGFD AFLPESNSLL PASDPILPKS PRIQKKDLDN
ELHKETVLEP TGDTPSKCYI QIGGMTCASC VSNIERNLKN EAGIYSVLVA LMASKAEVRY
NSEVTDPLKI AECVRELGFT ASVMENYEGS DGNLELVVRG MTCASCVHKI ESTLVREKGV
IYTSVALATN KAHVKYDAEV IGPRDIIKLI ENLGFEASLV KRDRSASHLD HSKEIRQWWK
SFFVSLIFCV PVMGMMIYMM IMDHKMNASH HHNATIEDRN LYHSHMFLEK QLLPGLSIMN
LLSFLFCVPV QFIGGRYFYI QAWKAFKHKS ANMDVLIVLA TTIAFSYSLV ILIVAMAEKA
KVNPITFFDT PPMLFVFISL GRWLEQIAKS KTSEALSKLM SLQATEATVV TLSSDNSILS
EEQVEVELVQ RGDVVKVVPG GKFPVDGRVI EGHSMADESL ITGEAMPVTK KPGSSVIAGS
INQNGSLLVS ATHVGMDTTL SQIVKLVEEA QTSKAPIQQY ADKISGYFVP FIVGISLLTL
IAWIIIGFLD FSLVEDFFPG YDRSISRTEA VIRFAFQASI TVLCIACPCS LGLATPTAVM
VGTGVGAQNG ILIKGGEPLE MAHKVQSVVF DKTGTITYGA PKVIQVKMVV EGNKMPRSRL
LAIVGTAENN SEHPLGAAIT KYCKQELGTE SLGTCTDFQA VPGCGIRCQV SNTEYLLKQA
DSDSEDSNQR SGVLVQISDT RLPANSHPLT MDPQPLSLVQ TAAYVVLIGN REWMRRNCLQ
LRPDIDEAMI EHERRGRTAV LVAVDNELCA MVAIADTVKP EAELAVHTLT SMGLEVVLMT
GDNSKTARAI AAQVGIRKVF AEVLPSHKVA KVEQLQQAGK RVAMVGDGVN DSPALAMADV
GIAIGTGTDV AIEAADVVLI RNDLLDVVAS IDLSKKTVKR IRINFVFALI YNLVGIPIAA
GVFLPIGLVL HPWMGSAAMA LSSVSVVLSS LLLKCYTKPS AEKLEAKLGN SRRQGSLSDV
SVHIGMGDLR RPSPKLSLLD RIVNYSRASI NSLRSDKHSL NSLVLSEPDK HSLLVGEALC
EEEIC
//
