ID A0A3Q2DAV3_CYPVA Unreviewed; 443 AA.
AC A0A3Q2DAV3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ribonuclease H {ECO:0000256|ARBA:ARBA00012180};
DE EC=3.1.26.4 {ECO:0000256|ARBA:ARBA00012180};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000016031.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000016031.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta type-B retroviral polymerase family.
CC HERV class-II K(HML-2) pol subfamily. {ECO:0000256|ARBA:ARBA00010879}.
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DR AlphaFoldDB; A0A3Q2DAV3; -.
DR STRING; 28743.ENSCVAP00000016031; -.
DR Ensembl; ENSCVAT00000024289.1; ENSCVAP00000016031.1; ENSCVAG00000018916.1.
DR GeneTree; ENSGT00940000170117; -.
DR OMA; ADCHMIS; -.
DR Proteomes; UP000265020; Unplaced.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR37984:SF10; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 167..344
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 443 AA; 50743 MW; EEBDDD9AD60472AA CRC64;
MPIKVNETVI PFKLDTGAHV NLLSWEDYKI MTVKSKIHPI KTKVTGYTGE RIPVKGGCIA
TFQHKGQQIQ AQLLIVDANV QPILGLKTCT KLNLVKRVFV VTSPGTVNDH DSLMEEYKDC
FEGLGCLPGE HKIFVDKSVS PVVHPCRKIP FALRNKLKEE LVRMEKLGVI KKIDEPTEWV
SSLVVVQKKT GALRTCLDPR DLNKAIKREH FKLPTREEIM AQFAGAKWFS KLDASSGFWQ
LRLDEESSRL CTFNTPEGRY RFLRLPYGIL SAPEVYHKTI HMIFEHIPGV ETMMDDIIVW
GSTRAEHDER LRQVLDKTRE VNLKLNKDKC EFGVKTLTFM GDVVSEEGVK PDPRKTSAIN
NMETPKNKDE VRRFLGMVTY LAKFVPQLSA QSAPLRILLE QKNEWVWSHE QEQCFLKLKK
ILTQEPVLQF YDPERSTRIS ADA
//
