ID   A0A3Q2DC10_CYPVA        Unreviewed;       740 AA.
AC   A0A3Q2DC10;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   Name=DHX40 {ECO:0000313|Ensembl:ENSCVAP00000016049.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000016049.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000016049.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   RefSeq; XP_015228201.1; XM_015372715.1.
DR   AlphaFoldDB; A0A3Q2DC10; -.
DR   Ensembl; ENSCVAT00000024309.1; ENSCVAP00000016049.1; ENSCVAG00000018991.1.
DR   GeneID; 107083468; -.
DR   KEGG; cvg:107083468; -.
DR   CTD; 79665; -.
DR   GeneTree; ENSGT00940000158902; -.
DR   OMA; VTSKPFM; -.
DR   OrthoDB; 5488182at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF234; ATP-DEPENDENT RNA HELICASE DHX40-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          27..198
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          230..409
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   REGION          693..740
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   740 AA;  83744 MW;  976EE42A177C321D CRC64;
     MSKPTRLAVK DSEPKHLPIY QHKNKLVQAV RKSPFLIVTG ETGSGKTTQL PQYLHEAGFC
     KNGKIGITQP RRVAAITVAQ RVAQEMKCTL GREVGYQVRF DDCTSQETAV KYMTDGCLLR
     EVLADPSLSQ YSVVILDEVH ERSLNTDILL GLLKNVFSDP AEAAKRRSFP LKVVVMSATL
     ESDKLSAFFN NCPVFEIPGR VFPVTCTFGS AVGPKDVERN FYVKEVVKVA LDVHISEKAG
     DILVFLTGQS EIEHACDLLF EKAENIDYRY DVQDRTVEGL LILPLYGSMP TDQQRQIFQP
     PPPGIRKCVV ATNIAATSLT INGIKYIVDS GFVKQLNHNS RVGMDVLEVV PISKSEAQQR
     AGRAGRTSAG KCFRIYTKEF WEKCMPEYTI PEIQRTSLTA VILTLKCLGV HDVIRFPYLD
     CPEERFILEA LKQLYQFDAI DRRGKVTKLG ELMVEFPLHP GLTRALLKSA SLGCQDLLLP
     VAAMLSVENI FIRPGHPDKQ KEAAKKHRAL AEKTGSINDF ATLLCVFNSC KSSDRPSAWC
     KENWIHWRAL KSAFSVETQL REILLRLQQR RDFPTESFDG NKSELLRRCL CSGYFTNVAR
     RSVGKVFCTM DGHGSMVHVH PSSSLFEQEA ELNWVIFHDV LVTSKTYIRT VCPIRYEWVK
     DLLPKLHEVD VYELSSVARQ EVTEDEMVKW ESKEAAKRQQ EASAEDVMKK LEKRNTEDSV
     SDARARYLQR KQQREQRKAL
//