ID A0A3Q2DDR4_CYPVA Unreviewed; 1452 AA.
AC A0A3Q2DDR4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Pleckstrin homology, MyTH4 and FERM domain containing H2 {ECO:0000313|Ensembl:ENSCVAP00000017266.1};
GN Name=PLEKHH2 {ECO:0000313|Ensembl:ENSCVAP00000017266.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000017266.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000017266.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_015229149.1; XM_015373663.1.
DR STRING; 28743.ENSCVAP00000017266; -.
DR Ensembl; ENSCVAT00000032235.1; ENSCVAP00000017266.1; ENSCVAG00000020482.1.
DR GeneID; 107084026; -.
DR KEGG; cvg:107084026; -.
DR CTD; 130271; -.
DR GeneTree; ENSGT00940000157675; -.
DR OMA; WCILIGK; -.
DR OrthoDB; 4538469at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13282; PH1_PLEKHH1_PLEKHH2; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22903:SF3; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY H MEMBER 2; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 660..755
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 769..877
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 913..1068
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1079..1410
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 201..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 451..498
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1432..1452
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 35..62
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 88..172
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 201..223
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 224..242
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..257
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..396
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 636..658
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1452 AA; 161828 MW; BFE1ED6B0ADA7269 CRC64;
MAEGEEAMSQ EDWKERCTLL EALLVKFRVQ IVKIRELTAD KIQQLETQVI DAEKRAFAAN
QQVRWMEEKL KAPGGHVGDS EMRLFQQCKE LRASLQDKEE VISQLEQQLE EQKQNRLQDA
KAVEEKAAKI KEWVMLRLSE FEGENAALRE TNKLQEAQIL ELQKQVQAFE QRSLSDRGVL
CKTGEAQRLS SLTFGSFQVR GKNPQVLTGP APSRTLSPQE ETDTLTEPPE RSIKHTASVD
TDGDVDRTNQ SGLVLSPREE SNAPKRSPEN VSHGGSCLSS SAASEGEGVC EAKGGFSRPC
SENYLTASDD SSSLFDDDMQ RAERPVFGLV EMSEAVGEEV GRSTTKLEDC TSEELNKRFQ
SQRLDSSSSS SEPTTPSPIL TPAPTPKRPN APMDNPASPK QPRLRTPAGG GLLSVSVVKK
HLSQPPVGSE AAHSQIRNAL SMLRPLQSQE NDLDPQLEDD METERITPPS SASPESRSER
TDCDSSGPCK PPTPPLHRLP SWESRIYAVA KSGIRLSDTS CSGHPSRDLS LQASYPAFVM
YTSLIYKNMT TPVYTTLKGK ATLLSSSPFS DESSSSEESS SSGEEDGSIC SSHASSGSRK
DSSPGSPRSL KRAVSVASMT SESDYAIPPD AYSTDTECSE PEQKLPKTCS SASDNGKSEP
MEKSGYLQKM VKTWKKTWKR RWFVLKDGEL LYYKSPSDVI RKPQGQIEVN ASSSITRGDG
KQVLQIVTGK HVCYLKADSP NLLEEWLRVL QSVLRVKAAS PLFTQPDIRP AMKGLLIKVK
HGYIKRVWCA LVGKTLYYFR SQEDKFPLGQ IKLWEARVEE VDRSKESDGE LKACGQSLEA
APFTVALHPQ EQSPTYLLIE SRHEKDSWLY HLSVAAGARV GKVGTEFEQL VGKLFQLDGD
PNSPIWRHPT LCFSKEALSS PLTTLPSQAL QTEAVKLFKT CQLFINVAID APAIDYHVSL
AQSALQVCLT HPELQNEFFC QLMKQTRMKQ PQGIAGPLQG WQFLALCVGL FLPQHPFLWL
LQVHLKRHGD ARTEVGKYAI YCQRSLERTQ QKGERQARPS RMEILSILLR NPYHHSLPFS
VPVHFLNNTY QVVSFDASTT VDEFQTRLNQ DTGMRKTGLS GFSLYTDDPT GRELEHCLSG
SIKICDILSK WEQASKEQHS GKSENTRTIR LTYKNRLYFS HQMRGESERE RMLLTYQTNE
AIVAGHFPVN KELALEMAAL LAQVEFGDFD RSFFASGLAQ SKSNQTLKQV LDRFYPKHYR
RTSSEEQQRQ LMQCLSARWA SLKGRSSSEC VRIYLTVARK WPFFGAKLFQ AETTTPSPES
GQSVWLAVHE DGISVLEHNS IKLLVTHPYK NLMTFGGCKE DFMLVVGHSI GTNTSKDKPA
EKHLFAMEAS KIREITLLIS SYINSAHQQK AAAHHLSAPA LMVAQPISLK SKELRSKSPP
ALGRPSKAPT LL
//
