ID A0A3Q2DDV9_CYPVA Unreviewed; 5034 AA.
AC A0A3Q2DDV9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Dystonin {ECO:0000313|Ensembl:ENSCVAP00000017067.1};
GN Name=DST {ECO:0000313|Ensembl:ENSCVAP00000017067.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000017067.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000017067.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR STRING; 28743.ENSCVAP00000017067; -.
DR Ensembl; ENSCVAT00000025626.1; ENSCVAP00000017067.1; ENSCVAG00000020365.1.
DR GeneTree; ENSGT00940000155008; -.
DR OMA; TMYASAT; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 16.
DR Gene3D; 1.20.58.1060; -; 2.
DR Gene3D; 1.20.58.60; -; 25.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR041615; Desmoplakin_SH3.
DR InterPro; IPR041573; Desmoplakin_Spectrin-like.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR049538; PCN-like_spectrin-like_rpt.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169:SF24; DYSTONIN; 1.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF17902; SH3_10; 1.
DR Pfam; PF00435; Spectrin; 20.
DR Pfam; PF18373; Spectrin_2; 1.
DR Pfam; PF21019; Spectrin_3; 1.
DR Pfam; PF21020; Spectrin_4; 1.
DR Pfam; PF21097; SR_plectin_7; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00150; SPEC; 31.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 27.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 539..596
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 4681..4716
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 4717..4752
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 4757..4829
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 182..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1319..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4855..4909
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4948..5034
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 393..420
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 732..769
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1241..1279
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1415..1456
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1776..1806
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1831..1898
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1983..2010
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2041..2068
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2256..2290
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2548..2575
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2622..2653
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2732..2787
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3678..3705
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4439..4466
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1345..1365
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4865..4909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4948..4970
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4977..5026
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5034 AA; 574599 MW; 3AD2ECA1E12601F4 CRC64;
MAYLSRTSTF SNSSFNTSFG SCDSILTEPF QINNSVFLNN NLAYGSRLEM LQQIANRVQR
DCVNGEDRLA LAKSALQSDT KRLESGIQFI NEAEVAGYLL ECENILRQQV VDIQILLEGK
FPFADQLVQR VSRLRDDLLA LRAECSAVYS KGRTLTTEQT KRMISGITQS LNSGFSQSIN
DSLTSDMTPS LTSGGLGTPG STFTSGFPSS LTPSLTSSLT PSLTPSNLMH LKHMQIRKPL
MKSSLADPSM TEEEVNLKYV QDLLNWVEEM QLQLERSDWG TDLPSVEMHL DNHKSVHRAI
EEFQTSLKDA RLSEIQMSMP LKLTYSEKLN KLGKQYEQLL NSSGERQNHL ESLHDFVSQA
TQELIWLNEK EEEEVAFDWS DRNSNISQKR DYHADLMREL DEKEETIKSV QEKAEQLMLK
NHPARLTIEA YKAAMQTQWS WILQLCSCVE QHLKENAVYF EFFSDAKVSM DYLKNLQDSI
QRKYKCNQSS SLQRLEDLIQ ESMDEKEQLL QYRNTVAGLV GRAKNIVQLR PRNPENPLRS
SIPVKAICDY RQIEITIYKD DECVLVSNSH RAKWKVINPA GNEAMVPSVC FSLPPPNKEA
VDLAASSCTK RSSHYGTNFT YYNLWQYTLI KTMLPGEHQQ VLSNLQSHFD EFLEDSKESE
VFTIGDCEQL ERDVAACKEY YQELLRSAER EEHEESVYNH YISEIRNIRM HLESQEEHLI
RQIRSPLERD DLEQSLQRIT EHERKMSELE RLKGDLDVMK EKCEQFFRQA AGSPSVMTLS
SELSVLVQSM SQVYSMSSIY MDKLKTVSLV VKHSQSAEAL VKTYESKLYE EDAVNSDIKS
IESVISTLKQ WRSEIDERQE VFHDMEDELQ KARVVSDRMF KAHNERDFDL DWHKEKADQL
SERWQNVHSQ IDSRLRDLDG ISKFLKHYRD TYSSVDQWIG ELETAQLKAQ ENKPDDSKAL
AEILNKQKVL VAEMEQKQSR IDECQKYSEQ YSSAVKDYEL QLMTFRAMVD SQHKSPLKKR
KTQSSSDAIQ QEFMDLRTRY TALVTLMTQY VKFAGETLKR AEDEEVSWFY PKTFMCNVLK
KCMVFKWFML LFLPLSVSIE EMVSKKEQIA EALKATQMML NKHGDKMTEE DRVKTQEQLN
ALSQAHSEIT QQCSEQATSA DEVGLESLSE KHKEFTEKLE EVCDNLTLTE NRLIGHQQQA
DTAESALQKD VLMNASALNE VIISTEKFLE ENRSKLTPAK IAMIERKLEE AKSKAELMNE
RAEESRKDLE KVVTTAIKQE SEKVHAAAVE QLEESKSKID GLLDWISNIG NENMSSLDQT
DHISKENGNP PGEASAKTLI DDDDANGNAL QTSGKDLGSN TKEENTASLD LDRQYDRVKA
HHQKILSQQQ DLVMATQSAQ ALLEKQANML SPEEKERLQK NIQDLKERYE TSLTQAEQQM
KQVQTVQEEL KKFNDDCEEF EDWLKQADVE IKELGAPAGS LNILSDKLQK QKIFSEDVIS
HKGDLRFITM SGQKVLDVAK TCESADAGSK NTLLHVDTSG TCSAVREKLD SAATRYKTLH
SQCNLLGNNL REVVDKYKKY DDSGTDLLKW LNVSEEEARK QQSEAIAADP KSLQKQLEDT
KALQSQMMEH QTAVDTLRKT AESLVTSEGN LLSNQDEIQE TIDDIVERYD NLSKSVSDRN
EKLQITLTRS MSVQDGLDEM IGWMEGVEAS VKEKDKVFLD ASCIGEMLKQ DIASRQSSIS
AIKAKVEKFV ETADPSTAQL LQSKMDALSK RFSDACDKHK QKVSQLEQLK EKVEEFDEIK
DKIQQFVMKR SQELHETDGP GKTFGELSQQ MQTTKAEMAE HANDMERLQT LCRELCEISP
DGNKAQLQSK IENVSNVFRS FKDAVKEKEE ELSSCQDQLG EFSSAVCMLT KWLEETNEKV
PAAKSSSSEQ NLEKDLQILT KCLNHHKRKL QRSVCKNCIV MSSELMGIQQ NMSFVTEGYT
NLGDTLKNRM EQLSDVLQEV KETQKETEKM MTWLKDMKNT AASWNAAAAE KDSVKTQLEQ
QKTFEDDMKR KQEQLQKLRE KLQGLISANP SSPEAAKWKK MLSEIDAAWM EITGSVEERK
QNLEQSNKNL EIFQTTDQQL SQWLSEKELM LGVLGPLSID PNMLKMQKQQ VQILQNEFKS
RKPHYEKLEE AASNILSSSG DTEPSSGKMV REKLNAISQK WQGLTGQLEQ RDCLIDQAMI
KTNEFQELLR GLSSTATELE EQLTNHHSSS TQPDAVKKQL EDVQNISAQL REERKKLKQA
EVVNAELSAL VTEDYLKADL VKQLESVSKP FKRLEDKAAK LIEQLNSTFA SSQQFHQTSK
DFQSWLAEKL QDQEKSLPIS AKVDILQQTL EEHVMYQKSL KEHEQAYNTI TGEGEMLLQN
TDGVEKLALQ GQLSTLSSNW EEVKKSSAEK VDKLQAALQK SQKFQENVEK LSSWIQDCEA
NDSRIKVNVD PVAVEGAISQ VKALQKDVDK HRGLLEQLNA SAESLLEVVN TDTEAVKEEK
DHIGTRLDQL TEGLQVKREQ LEKISHTVKE FNDAFKEARG QLEGAKKQVD SFKSKGVEAQ
SNKYLTNLKA QHKGLEGVQN QVEHMKTLAK DLVVDVPDAE GVTDLLLQVD NIEKDYSNLN
TKLEEACQEL ESKLQGIGQF QTSIREMFTS FTELDDELDS MPPVDLDLAT LRGQQQSIQS
FMSKLQELMA STNYAGESCK KMLKESEASP ELLGLKRDLD ALSKQCNKLM DRSKGREVQV
QSTLNKLEEL YDKVHQVEDK LLRAVDREAS QEAVGSETDM INQQLDALKT FQKEDIDPLQ
TQLHDINLLG QGLIQNAAKG STNKKIEDDL DAINSKWNTL NKKVAERSAQ LHEALLHCGR
FQDALESLLS WLTDTEELMA TQRPPSAEFK VVKAQIQEQR LLQRLLNDRK PTVELIKNEG
GKVAELAEAA DKEKITKEIE CLGQRWDNLL KKAESRQKQL ESILGVTQQF HETLEPLNEW
LAATEKHLAS CEPIGTETSK LEDQIAQHKS LEEEIMGHSK DLLQAVSLGQ MLKTASSVEE
KEFVQSRLDT TQASYIELQE RCRRKADMLH QALANAQLFG EDEVALMNWL SEVHSKLKEV
SVQDHKSDVL EKQLAEQRIL QGDIELRKKN VDQAISNGME LLKQTTGDEV VIIQGKLDGI
KSKYAEINSM SENVLKTLEG VLSLSNKLQH HHKDLNTWLE KAEAELKIFA DQEPVGDQLI
HSQNKQKDLL KETKDKKPVL DKLNELSSSL LDLIPWHTRE SLDKLVTDDN ERYRVVCETI
TQQVDKINAD ILKSQQFEKA ADTELSWLSN AEGKLLSMCE IRLEHDQTTA QLQAQKIFSM
DIMKHKDVVD EIVKTGKAIM NSKNPEEREA LKEKIQTLLE KYSTVSQLNS ERCLQLERAQ
SLAGQFWETY EEMWPWLQET LSTFSQLPPP AIEYETLRQQ QEELRQMREL IAEHKPHIDK
MNKTGPQLLE LSPVEGAPIR EKYTSADQLY TKLKADVKER AASLDEAISK STQFHDKIDP
MLESLERIAE RLRQPPSISV EIDKIKEQIT ENKAVTVDLE KLQPAYETLR QRGEEMIARS
EGPDKDLSAK AVQDKLDHMV FLWNDIQALL EEREAKLLDV MDLADKFWCD HCALIVTIKD
SQDLLRELEE PGVDPSVVKQ QQEFVEGFKE EIDGLQEELD VVRNQGAELM TACGEPDKPV
IKKSVDEVNS AWEHLNKSWK ERVERLEEAM QAAVQFQDGL QGMFDWVDIL ENKLDSMSPV
GTDLETVKQQ IVELKEFKGE AYQLQIEMER LNHQAGLLLK KVTEEADRCA IKEPMSELRM
LWENLDEKII SRQHKLEGGL LALGQFQHAL DELLAWMSHT EELLNEQRKA AGDPKAIEIE
LAKHHVLQID VLAHKATVET VNKAGNELVE SSAGEEASSL QSKLENLNHR WKAILEKTDQ
RKKQLEASLL QAQGFHGEIE DMQQWLKDTE RQLLASKAVG GLPDTAREQL NAHLELCSTF
EAKGELYRKL LEKGGQLLAM TPEGPDINTE QDLSCLKEKW EAVQAKVAER KAKLEEALTL
ATDFHSSLQD FIVWLTQAEQ TLNMVSPASL ILETIMFQID EHKMFVTEVN SHREHIIELD
KTGTHLKYFS QKKDVVLIKN LLLSVQSRWE KLVQRSVERG RVLDDARKRA KQFHETFNKL
MEWLEESEKA LDSEVEIAND PDKIKMQLAQ HKEFQKALGS KHSVYDTTAR TGRALKDKTV
LQDDKQKLDD MLSELRDKWD TVCGKSVERQ NKLEEALLFS GQFTDALQAL IDWLYKVEPQ
LAEDQPIHGD IDLVLNLIDN HKVFQKELGK RTVSIQALKR SAKELVENSH DDSSWVKAQM
QELSTRWDTV CNLSVSKQTR LEQALCQAEE FHSSVHILLE WLAEAEQSLR FHGSLPDDEE
ALRALIEQHK DLMKKLEEKR VALNKATSMG EAILSICHPD SITTIKHWNT IIKARFEEVQ
AWVRQHQQRL GLALTELLAT QDLLENLLTW LQWAETNLSD RDRETLPQEI EEIKSLIAEH
QTFMEEMTRK QPDVDKITKT HKRKPAAEPL IQSQIPVLDK GRAGRKRSPT QTMYTSTTQA
LIETKNPRVN LLVTKWQHVW LLALDRRRKL NDALDRLEEL KEFANFDFDV WRKRYMRWMN
HKKSRVMDFF RRIDKDQDGK VTRQEFIEGI LSSKFPTSRL EMSAVADIFD RDGDGYIDYY
EFVAALHPNK DAYKPLTDAD KIEDEVTRQV AKCKCPKRFQ VEQIGANKYR FGDSQQLRLV
RILRSTVMVR VGGGWMALDE FLVKNDPCRA KGRTNMELRE KFILPEGATQ VMASFRYRGR
RSRPSSRGAS PNRSTSSQSY PTSQNITRNY DKPWLTNSKP STPLKSSDSF EIQGSKLRLP
GYLSGKGFQS GEEGSLINNA VLKARAQTIE SRKNSSRPGS KAGSRGSSRR GSDASDFDIS
DIQSVCSDVS ETVGESTRAT PRPTSRQQGG KQSKIPTPQR RTTPTSKLAK GSKR
//
