ID   A0A3Q2DEC5_CYPVA        Unreviewed;       846 AA.
AC   A0A3Q2DEC5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Phospholipase {ECO:0000256|PIRNR:PIRNR009376};
DE            EC=3.1.4.4 {ECO:0000256|PIRNR:PIRNR009376};
GN   Name=PLD2 {ECO:0000313|Ensembl:ENSCVAP00000016949.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000016949.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000016949.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-
CC         sn-glycero-3-phosphate + choline + H(+); Xref=Rhea:RHEA:14445,
CC         ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57643, ChEBI:CHEBI:58608; EC=3.1.4.4;
CC         Evidence={ECO:0000256|PIRNR:PIRNR009376};
CC   -!- SIMILARITY: Belongs to the phospholipase D family.
CC       {ECO:0000256|ARBA:ARBA00008664, ECO:0000256|PIRNR:PIRNR009376}.
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DR   AlphaFoldDB; A0A3Q2DEC5; -.
DR   Ensembl; ENSCVAT00000025480.1; ENSCVAP00000016949.1; ENSCVAG00000020017.1.
DR   GeneTree; ENSGT00940000160229; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0070290; F:N-acylphosphatidylethanolamine-specific phospholipase D activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR   GO; GO:0004630; F:phospholipase D activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006654; P:phosphatidic acid biosynthetic process; IEA:InterPro.
DR   CDD; cd01254; PH_PLD; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR   Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   InterPro; IPR016555; PLipase_D_euk.
DR   InterPro; IPR015679; PLipase_D_fam.
DR   InterPro; IPR001683; PX_dom.
DR   InterPro; IPR036871; PX_dom_sf.
DR   PANTHER; PTHR18896; PHOSPHOLIPASE D; 1.
DR   PANTHER; PTHR18896:SF121; PHOSPHOLIPASE D2; 1.
DR   Pfam; PF00614; PLDc; 1.
DR   Pfam; PF13091; PLDc_2; 1.
DR   Pfam; PF00787; PX; 1.
DR   PIRSF; PIRSF009376; Phospholipase_D_euk; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00155; PLDc; 2.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   SUPFAM; SSF64268; PX domain; 1.
DR   PROSITE; PS50035; PLD; 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PIRNR:PIRNR009376};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963,
KW   ECO:0000256|PIRNR:PIRNR009376};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963,
KW   ECO:0000256|PIRNR:PIRNR009376};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          364..391
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   DOMAIN          663..690
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
SQ   SEQUENCE   846 AA;  97935 MW;  0D7E9A4511FEE923 CRC64;
     RLSEIKDAGV PYLMPDTPIT CKVDNTEKYT TRSKVHVGTL YTLRLTHGHF HWVVKRKYKH
     FQELHRDLYK HKMMIHYFPL KRSAAMPMFN ITTSLRFRLN NAFCRNDHSM LEFLSVGPLS
     FVTDLGPKGL EGPIMKRSGG HRILGLNCIG HHQVCYRWSH RWLVVKDSFL LYMSRDNSEI
     DFVLLFDPKF DIKVGNSHTG TEYGVSIESY TRNLIIKCSS YRQSHWWSHE IRRLAEDCDF
     LKEHRFGGFA PPREDTLTKW YVNGRDYFAD LADALEKAKE EIFITDWWLS PEIFLKRPAT
     SNHWRLDHIL KRKAEQGVKV CVLLYKEVEM ALGINSDYSK RTLMNMHPNI KVMRHPDHVS
     SAVVLWAHHE KMVAIDQTVA FVGGIDLAFG RWDDREYRLA DLDNQTETDL TGNTKLWLGK
     DYSNFIKKDW TLLDRPFEDN IDRTQVPRMP WRDLSAAMHG KAARDVARHF IQRWDFTKTF
     KTKYKDNFYP YLLPKSHTTA DSLPYTVPGS QRAKVQVLRS ADSWSAGSCE NSILQAYIHT
     IETSEHFIYI ENQFFISCAE DKVIQNGIGD AIVDRILRAH REQKKYRVFV VIPLLPGFEG
     DITTGGGNAI QAIMHFTYRT MCRGEHSILA RLREGMFCFF WTEYITFCGL RTHSWLSGFN
     VTELIYVHSK ALIADDRRYI IGSANINDRS MLGSRDSELA VFVEDQERVP SIMGGQEYEA
     GPLALALRKE CFRVLVGATS DPSINIDDPI SDDFFFVTWN ETARQNTAIY EKVFKCLPCN
     SVHNMNLLRN YCCQEPLCDA DPARAAEELK AIRGLLVHFP LKFLCEENLL PSLNCKEGMA
     PTDLWT
//