ID   A0A3Q2DF53_CYPVA        Unreviewed;       650 AA.
AC   A0A3Q2DF53;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Protein 4.1-like {ECO:0000313|Ensembl:ENSCVAP00000017841.1};
GN   Name=EPB41L2 {ECO:0000313|Ensembl:ENSCVAP00000017841.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000017841.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000017841.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2DF53; -.
DR   Ensembl; ENSCVAT00000026633.1; ENSCVAP00000017841.1; ENSCVAG00000021006.1.
DR   GeneTree; ENSGT00940000155617; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0003779; F:actin binding; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR   CDD; cd14473; FERM_B-lobe; 1.
DR   CDD; cd13184; FERM_C_4_1_family; 1.
DR   CDD; cd17106; FERM_F1_EPB41L; 1.
DR   Gene3D; 1.20.80.10; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR008379; Band_4.1_C.
DR   InterPro; IPR019749; Band_41_domain.
DR   InterPro; IPR000798; Ez/rad/moesin-like.
DR   InterPro; IPR014847; FA.
DR   InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR   InterPro; IPR035963; FERM_2.
DR   InterPro; IPR019748; FERM_central.
DR   InterPro; IPR019747; FERM_CS.
DR   InterPro; IPR000299; FERM_domain.
DR   InterPro; IPR018979; FERM_N.
DR   InterPro; IPR018980; FERM_PH-like_C.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR007477; SAB_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR   PANTHER; PTHR23280:SF20; BAND 4.1-LIKE PROTEIN 3; 1.
DR   Pfam; PF05902; 4_1_CTD; 1.
DR   Pfam; PF08736; FA; 1.
DR   Pfam; PF09380; FERM_C; 1.
DR   Pfam; PF00373; FERM_M; 1.
DR   Pfam; PF09379; FERM_N; 1.
DR   Pfam; PF04382; SAB; 1.
DR   PIRSF; PIRSF002304; Membrane_skeletal_4_1; 2.
DR   PRINTS; PR00935; BAND41.
DR   PRINTS; PR00661; ERMFAMILY.
DR   SMART; SM00295; B41; 1.
DR   SMART; SM01195; FA; 1.
DR   SMART; SM01196; FERM_C; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF47031; Second domain of FERM; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS00660; FERM_1; 1.
DR   PROSITE; PS00661; FERM_2; 1.
DR   PROSITE; PS50057; FERM_3; 1.
PE   4: Predicted;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          4..286
FT                   /note="FERM"
FT                   /evidence="ECO:0000259|PROSITE:PS50057"
FT   REGION          488..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..506
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   650 AA;  72470 MW;  8B00691C95DF929E CRC64;
     MKVVVCHVTL LDGTDFTCEV EKRAKGQYLF FKVCEHLNLL EKDYFGLTYK DNHDEKCWLD
     PTKEIKRQIR SNNWQFVFSV KFYPPDPSQL TEDITRYLLC LQLREDVASG RLPCSFVTHA
     LLGSYTLQAE FGDHEPDPPR PVDFISQLKL ESNQNKEMEE KILELHKSHR GMTPAQADLQ
     FLENAKKLSM YGVDLHPAKD SEGVDIMLGV CANGLLVYKD RLRINRFAWP KILKISYKRN
     NFYIKIRPGE TEQFESTVGF KLQNHRSAKK LWKVCVENHS FFRLNASEAP TKARFLTLGS
     KFRYSGRTQA QTRLASSLID RPAPSFERTS SKRISRSLDG APMISITEAG SETAENGRDP
     HLELHSDSKD LDKTQDEVLK HQASISQLKR SFMEAPPPSP PQPNQWEKRL TSSPATTIRV
     QQQQVSLEDE IASVLLSRRS AAECCSSTRP PCSATESTLE GAVTTCSAAA PTAVCTSSLS
     HPVSALSATE VSVPQTEASP ADNPSSDTKE PAKPPVVKTE MVTISDTFAA QKTEIATKEV
     PIVHTETKTI TYEAAQLDGN GDGEPGVLMT AQTITSESLC TTTTTHITKT LKGGLSETRI
     EKRIVITGDC DIDHDQALAQ AIKEAKEQHP DMSVTRVVVH KETELAEEED
//