ID   A0A3Q2DG93_CYPVA        Unreviewed;       440 AA.
AC   A0A3Q2DG93;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Beclin-1 {ECO:0000256|ARBA:ARBA00018490};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000018067.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000018067.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome
CC       {ECO:0000256|ARBA:ARBA00004419}. Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004406}. Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004481}. Golgi apparatus, trans-Golgi network
CC       membrane {ECO:0000256|ARBA:ARBA00004150}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004150}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004170}. Mitochondrion membrane
CC       {ECO:0000256|ARBA:ARBA00004318}; Peripheral membrane protein
CC       {ECO:0000256|ARBA:ARBA00004318}.
CC   -!- SIMILARITY: Belongs to the beclin family.
CC       {ECO:0000256|ARBA:ARBA00005965}.
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DR   AlphaFoldDB; A0A3Q2DG93; -.
DR   Ensembl; ENSCVAT00000032576.1; ENSCVAP00000018067.1; ENSCVAG00000021354.1.
DR   GeneTree; ENSGT00390000008164; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 6.10.250.3110; -; 1.
DR   Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR   InterPro; IPR007243; Atg6/Beclin.
DR   InterPro; IPR038274; Atg6/Beclin_C_sf.
DR   InterPro; IPR041691; Atg6/beclin_CC.
DR   InterPro; IPR040455; Atg6_BARA.
DR   InterPro; IPR029318; BH3_dom.
DR   PANTHER; PTHR12768; BECLIN 1; 1.
DR   PANTHER; PTHR12768:SF4; BECLIN-1; 1.
DR   Pfam; PF04111; APG6; 1.
DR   Pfam; PF17675; APG6_N; 1.
DR   Pfam; PF15285; BH3; 1.
PE   3: Inferred from homology;
KW   Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          95..119
FT                   /note="Beclin-1 BH3"
FT                   /evidence="ECO:0000259|Pfam:PF15285"
FT   DOMAIN          125..251
FT                   /note="Atg6/beclin coiled-coil"
FT                   /evidence="ECO:0000259|Pfam:PF17675"
FT   DOMAIN          254..434
FT                   /note="Atg6 BARA"
FT                   /evidence="ECO:0000259|Pfam:PF04111"
FT   COILED          160..208
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   440 AA;  50224 MW;  9946BA34BF82E81A CRC64;
     MEGSKSASTT MQVSFVCQRC SQPLKLDTSF NVLDRVTIQE LIAPLVTVTP SSKQTDSSGG
     EAAPEVDDKA AKSFHCRMMS TESANSFTLI GDASDGGTME NLSRRLKVTS DLFDIMSGQT
     DVDHPLCEEC TDTLLDHLDT QLNITENECQ NYKQCLELLS NLQVEEEETL QAELQQLKNE
     EETLVQELEA VEEQRAAVAK ELAQSRIQSQ QLDTEELQYQ KEYSEFKRQQ LELDDELKSV
     DNQMRYCQIQ LDRLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW NEINAAWGQT
     VLLLHALANK MGLRFQRYRL VPYGNHSYLE SLTDKSKELP LYCSGGLRFF WDNKFDHAMV
     AFLDCVQQFK EEVEKGDTGF CLPYRMDVEK GKIEDTGGSG GSYSIKTQFN SEEQWTKALK
     FMLTNLKWGL AWVTSQFYNR
//