ID A0A3Q2DIM6_CYPVA Unreviewed; 408 AA.
AC A0A3Q2DIM6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Sterile alpha motif domain containing 8 {ECO:0000313|Ensembl:ENSCVAP00000019048.1};
GN Name=SAMD8 {ECO:0000313|Ensembl:ENSCVAP00000019048.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000019048.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000019048.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sphingomyelin synthase family.
CC {ECO:0000256|ARBA:ARBA00005441}.
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DR RefSeq; XP_015236753.1; XM_015381267.1.
DR AlphaFoldDB; A0A3Q2DIM6; -.
DR STRING; 28743.ENSCVAP00000019048; -.
DR Ensembl; ENSCVAT00000032978.1; ENSCVAP00000019048.1; ENSCVAG00000022376.1.
DR GeneID; 107088839; -.
DR KEGG; cvg:107088839; -.
DR CTD; 142891; -.
DR GeneTree; ENSGT00940000155540; -.
DR OMA; GADWLCN; -.
DR OrthoDB; 1343173at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016780; F:phosphotransferase activity, for other substituted phosphate groups; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd09515; SAM_SGMS1-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR045221; Sphingomyelin_synth-like.
DR InterPro; IPR025749; Sphingomyelin_synth-like_dom.
DR PANTHER; PTHR21290:SF25; SPHINGOMYELIN SYNTHASE-RELATED PROTEIN 1; 1.
DR PANTHER; PTHR21290; SPHINGOMYELIN SYNTHETASE; 1.
DR Pfam; PF14360; PAP2_C; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 142..166
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 190..214
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 226..249
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 9..75
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
SQ SEQUENCE 408 AA; 47355 MW; 2FD368B46A225F31 CRC64;
MTQLSVRYWT PKHVARWLKE EGFCDYVDLL CNKHRLDGTS LLALSEYDLR SPPLELKVLG
DIKRLMMSVR KLQKQNLDVL EELGVPFDGL SPSSSGSNLE WLCNGDPSRD CDSTNTAPVG
EEYQQYTNGK YKQQMRRLDP EYWKTVLSSV YVVFVFGFTS FVMVIVHERV PDMRTYPPLP
DIFLDSMPRI PWAFAMAEAC GVILCNIWLL VLLLHKHRSI LLRRMCSLMG TVFMLRCITM
FVTSLSVPGQ HLQCTRKMYG DMWAKLQRAV AIWSGFGMTL TGVHTCGDYM FSGHTVVLTM
LNFFVTEYTP RSWNFIHTLS WVLNLFGIFF ILAAHEHYSI DVFIAFYITT RLFLYYHTLA
NTRAYQQSRR ARIWFPMFSF FECNVNGPVP NEYCWPFPKP AAMKRLIG
//
