ID   A0A3Q2DJ79_CYPVA        Unreviewed;       680 AA.
AC   A0A3Q2DJ79;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE            EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000019293.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000019293.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + CoA + propanoate = AMP + diphosphate + propanoyl-CoA;
CC         Xref=Rhea:RHEA:20373, ChEBI:CHEBI:17272, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57392,
CC         ChEBI:CHEBI:456215; EC=6.2.1.17;
CC         Evidence={ECO:0000256|ARBA:ARBA00000787};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:20374;
CC         Evidence={ECO:0000256|ARBA:ARBA00000787};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC         Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:456215; EC=6.2.1.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00001884};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:23177;
CC         Evidence={ECO:0000256|ARBA:ARBA00001884};
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
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DR   RefSeq; XP_015228504.1; XM_015373018.1.
DR   AlphaFoldDB; A0A3Q2DJ79; -.
DR   STRING; 28743.ENSCVAP00000019293; -.
DR   Ensembl; ENSCVAT00000028428.1; ENSCVAP00000019293.1; ENSCVAG00000022663.1.
DR   GeneID; 107083643; -.
DR   KEGG; cvg:107083643; -.
DR   CTD; 84532; -.
DR   GeneTree; ENSGT00940000165253; -.
DR   OrthoDB; 144557at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0050218; F:propionate-CoA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF83; ACETYL-COENZYME A SYNTHETASE; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU361147};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          54..109
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          111..500
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          559..638
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   680 AA;  75716 MW;  805354E250674592 CRC64;
     MWLPCRCAAK YVAASFSRGV SASFLHALRR NRSSWNAAAF MPESSGFEGV SGRDALHDYS
     VSHSESFWAA VARQRLSWIR PFDVVQDCDL SQGRISWFEG GKLNVSVNCL DRHVHTCPER
     VALIWERDEQ GSEVRYTYKE LLEMTCRLGN LLRRQGVKKG DCVTIYMPTC PLAVASMLAC
     ARIGAAHNVV FAGFSAEALA ERIRDAQSST VITVNQGVRG GKITELKRTV DAAVRSCPSV
     QQVFVAMRTE KQVEMTDRDF VLEEEMLKED VVCEPAPMDS EDVLFLLYTS GSTGKPKGLV
     HTQAGYLLYA AFTHRYVFGY HDGDVFGCVA DIGWITGHSY TVYGPLANGG TTVLFESTPV
     YPDPGRYWEM VERLRINQFY GAPTAIRLLI KYGDQWVKKY DRSSLTTLGS VGEPINTEAW
     EWYNRVVGEG RCPVVDTWWQ TETGGICIAP KPSEPDAEIV PGMAMRPFFG IKPVLMDTEG
     KVLTSNNTSG ALCMAQPWPG MARTIHNNHQ RFIETYFQPY PGYFFTGDGA YRSEKGYYQI
     TGRLDDVINV SGHRIGTAEI EDVVNQCPAV AESAVIGYSH SIKGQGVYAF VVLKKGVDIQ
     EADISKQLNN MVSEKIAKYA CPEFVQFAKR LPKTRSGKIM RRVLRKVVEC DLDSLGDLST
     LDDPAAVQEI IKGHEKLLSK
//