ID A0A3Q2DJL3_CYPVA Unreviewed; 829 AA.
AC A0A3Q2DJL3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Potassium calcium-activated channel subfamily N member 3 {ECO:0000313|Ensembl:ENSCVAP00000019347.1};
GN Name=KCNN3 {ECO:0000313|Ensembl:ENSCVAP00000019347.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000019347.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000019347.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_015236072.1; XM_015380586.1.
DR RefSeq; XP_015236073.1; XM_015380587.1.
DR AlphaFoldDB; A0A3Q2DJL3; -.
DR STRING; 28743.ENSCVAP00000019347; -.
DR Ensembl; ENSCVAT00000028513.1; ENSCVAP00000019347.1; ENSCVAG00000022704.1.
DR GeneID; 107088424; -.
DR KEGG; cvg:107088424; -.
DR CTD; 3782; -.
DR GeneTree; ENSGT00950000182904; -.
DR OrthoDB; 4200919at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0016286; F:small conductance calcium-activated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 2.
DR InterPro; IPR004178; CaM-bd_dom.
DR InterPro; IPR036122; CaM-bd_dom_sf.
DR InterPro; IPR015449; K_chnl_Ca-activ_SK.
DR InterPro; IPR013099; K_chnl_dom.
DR PANTHER; PTHR10153; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR10153:SF40; SMALL CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNEL PROTEIN 3; 1.
DR Pfam; PF02888; CaMBD; 1.
DR Pfam; PF07885; Ion_trans_2; 1.
DR Pfam; PF03530; SK_channel; 1.
DR PRINTS; PR01451; SKCHANNEL.
DR SMART; SM01053; CaMBD; 1.
DR SUPFAM; SSF81327; Small-conductance potassium channel; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 337..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 366..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 417..434
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 548..565
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..597
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 615..691
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000259|SMART:SM01053"
FT REGION 21..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..269
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..829
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 696..723
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 30..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..96
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 130..157
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 829 AA; 90528 MW; 6E6B49197D112EEC CRC64;
MEPPPSLSLA LLGGSEDEDQ RFLLPLGSIS HPSTAGNMPG SNHSNHTGAS SIDRLNGSTP
SPSSTTPNLP PASLPKLPLS SPGAQPLPPP IPNALHPTST PLSSCLGSQH SLSGDNSPVY
NAFFYSSHSP SMERERDRDR DRERDRGSKH RQASPLVHRR DSNPFTEIAM SSCKYTGGVM
KPLSRLSASR RNLIESDSSS ETKEGGVSVV AGASAAAGHD RQREAPPTYS ETQSSTHPPP
IQSPPEIVIS SKEDSPYPRR GYDNTDSMSN QMSIYHQNHA LVESRRGQSE RGSRQVGVTA
AGSGARGSTS KAPKRKNQNI GYKLGHRRAL FEKRKRLSDY ALIFGMFGIV VMVIETELSW
GVYNKSSMYS LALKCLISLS TVILLGLIIA YHAREVQLFV IDNGADDWRI AMTMERVLLI
ALELLVSAVH PVPGDFKFHW RARLAFSYTP SHAEADLDMV LSVPMFLRLY LIARVMLLHS
KLFTDASSRS IGALNKVHFN TRFVMKTLMT ICPGTVLLVF SISLWIIAAW TVRVCERYHD
AQDVTSNFLG AMWLISITFL SIGYGDMVPH TYCGKGVCLL TGIMGAGCTA LVVAVVARKL
ELTKAEKHVH NFMMDTQLTK RIKNAAANVL RETWLIYKHT KLMKKIDHSR VRKHQRKFLQ
AIHQLRSVKM EQRKLSDQAN TLVDLSKMQS VMYELMSELN DRSEDLERQM LSLEQRVEQL
TAGFNALPAH LSATLSAQHA ALVHLLRDRD ARDGRGGGSG GGGAVVPLSP TASLSNAAVS
VSPIQVAAPP STLAQISSLS LESPLSPPPV SPEVSLEATP NPNTCSSSC
//
