ID A0A3Q2DKI5_CYPVA Unreviewed; 985 AA.
AC A0A3Q2DKI5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Chloride voltage-gated channel 1 {ECO:0000313|Ensembl:ENSCVAP00000020056.1};
GN Name=CLCN1 {ECO:0000313|Ensembl:ENSCVAP00000020056.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000020056.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000020056.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_015226202.1; XM_015370716.1.
DR AlphaFoldDB; A0A3Q2DKI5; -.
DR STRING; 28743.ENSCVAP00000020056; -.
DR Ensembl; ENSCVAT00000015338.1; ENSCVAP00000020056.1; ENSCVAG00000001174.1.
DR GeneID; 107082177; -.
DR CTD; 567478; -.
DR GeneTree; ENSGT00940000157383; -.
DR OMA; QPYYYAD; -.
DR OrthoDB; 1194at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03683; ClC_1_like; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 2.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720:SF4; CHLORIDE CHANNEL PROTEIN 1; 1.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122};
KW Ion channel {ECO:0000256|ARBA:ARBA00022882};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 110..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 227..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 340..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..500
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 41..87
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..764
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 838..985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 73..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 698..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 735..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..902
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..972
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 985 AA; 108408 MW; 8CED1CBC0B587DCC CRC64;
MAADASQRKA LRYQQTLLYG EYREQLGNFA RREAARLLTE RQCRRQAGEN SSARGRRGHG
RRHHPHLNPA ILESHQSPGS STTKPQPYSK CQDCLARVRR YIVTKMGEDW IFLILLGLTM
ALVSWSMDYA SAKSLQAYKW IYGELKSNVA LQYLAWVTYP IILIVFSSLF CHLVSPQAIG
SGIPELKTIL RGVVLKEYLT LKAFIAKVIG LTAALGSGMP VGKEGPFVHI ASICAAVLSR
FMSIFSGVYE NPYGYTDILT VGCAVGVGCC FGTPLGGVLF SIEVTSTYFA VRNYWRGYFA
ATFSAFIFRV LSVWNKDAVT ITALFKTNFR MDFPFDLQEL PAFAIIGISC GFLGAFFVYL
NRQVVLFMRR PTALTRFLTK HRLIYPGAVT LIISTFTFPP GFGQFMAGEL MPRECINSLF
DNFTWTKISD SSAPPGLGRS AAWLHPHVSV FLILLLFFIM KFWMSAVSTT MPIPSGAFMP
VFILGAAFGR LVGEIMATLF PNGILFDGIV YRILPGGYAV IGAAAMTGAV THTVSTAVIC
FELTGQISHI LPMMVAVILA NMVAQGLQPS LYDSIIQVKK LPYLPELALG HISKYNIFVE
DIMVRKVKFL SSQSTFRELN HLLESTALKT IPLVDSKESM ILLGSIERTE LQAVLDWWLS
PERRVFERGP SSPGQGSKLS WESFTFVDEE GEESNDKTVS PVQEGCNGPI PSPSSNEPST
NHTGSDKRKL SSVRRTLQRL FSSSSSSDQP ETQKDMPPPL TDTMSPEEIK AWEEEELDKP
VDMEQIRIDP SPFQLVERTS LHKTHTLFSL LGLSHAYVTS IGKLVGVVAL KELQKAIEGS
TRSGVRLRPP LASFRDASRK TKKHQPPSST ASSPTRDRDM WGEGSRRESE LLRRESREDS
QGKTVSLRGA AGSETVPSSP SSAGSTSGSS TNSRGAEGVS QGDPSPSTST SSPSPPVSPV
SHTSQVLTLS SLQEERESEE SDEQV
//
