ID A0A3Q2DLL7_CYPVA Unreviewed; 930 AA.
AC A0A3Q2DLL7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Toll-like receptor 13 {ECO:0000313|Ensembl:ENSCVAP00000020516.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000020516.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000020516.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3Q2DLL7; -.
DR Ensembl; ENSCVAT00000014140.1; ENSCVAP00000020516.1; ENSCVAG00000002007.1.
DR GeneTree; ENSGT00940000163999; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF551; LOW QUALITY PROTEIN: TOLL-LIKE RECEPTOR 13-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 720..743
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 769..910
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 930 AA; 108275 MW; ED3A74898EC1DB84 CRC64;
IHSGLKTSLS TKFYELRKYF YLIYTVVFYL STYIFFFLKD DIPKDAVSVQ LSNNLIQKIN
KEDLSEMSKL RILNLGHNQI SSVEDGSFND LVSLETLNMG DNKLVNLEAN MFQGLSNLTV
LDLSNNYIEF IHNSSFQFLT RLQTLDLENN FIGQVIYIQP ILQLPQLQIL NLNGYQNLTF
ETKDLTLNFS SSLKEFAISG CNLKMFSITT PVFPYLEKIN LSAAGQYDVL KWNIPDKTIL
RHVNTLFLVE PVLSFKGVHK VLKSFQSLRY LRLQFLHEWI RDGLLSAVCK IPTLRKLDIF
SILHGSTSKL APCSQLTELD LFFTEIDELS EGSVRSMRQL RSLNVSTNQL SKVPYDIRSL
SSLQILKLDN NIISDLNCDD FLNTTQLTEL YLHSNRIGKL ERCVLENLNE LKLLNLSNNQ
LKAVGETFQF SLFNLEILDI SDNKVFYIDY GYFQALGNLK VLNVVRDRMG RVKHRSFQEL
KNLETLNVSL SHFEATFRGL NHLENMTIHL FAGDKNLQSN GNTFFFSITS LKTLSIICKG
HEYPSFCSLP VRMLKTMKYL QSFRAVNVNL KDPNNDTFKF NKHLESLALT MTDLSNLDSD
LFHPIPHLKT LDLSETNIKS LDFLKLANLS ALRYLKMTGN DINVIDDAVF QFLPSLTYLN
LSNNPFTCDC SNIGFIQWLK NNKQTQVVNA HQYKCSYPLN KQGNLLLDFD IQSCWKDFSF
VYFISSTSLV VLTLLTSFIY NFLRWHLIYT FHLFLAYLYE NKKKKQNNHN FDAFVSYNIH
DEHWVYRELL PVLEEEQGWK LCLHHRDFQP GKPIIENITD AIYGSRKTIC VISRNYLQSE
WCSREIQMAS FRLFDEKKDV LILLFLEDIP PHHLSPFYRM RKLVKERTYL SWPQAAQHPG
VFWQNVRRAL QVRRLLNIYF SQNLVVKDWL
//
