ID A0A3Q2DLQ0_CYPVA Unreviewed; 672 AA.
AC A0A3Q2DLQ0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Aggrecan core protein {ECO:0000256|ARBA:ARBA00039399};
DE AltName: Full=Cartilage-specific proteoglycan core protein {ECO:0000256|ARBA:ARBA00042947};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000020348.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000020348.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00323}.
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DR AlphaFoldDB; A0A3Q2DLQ0; -.
DR Ensembl; ENSCVAT00000014589.1; ENSCVAP00000020348.1; ENSCVAG00000001701.1.
DR GeneTree; ENSGT00940000155971; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005540; F:hyaluronic acid binding; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:InterPro.
DR CDD; cd03517; Link_domain_CSPGs_modules_1_3; 2.
DR CDD; cd03520; Link_domain_CSPGs_modules_2_4; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 4.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000538; Link_dom.
DR PANTHER; PTHR22804:SF42; AGGRECAN CORE PROTEIN; 1.
DR PANTHER; PTHR22804; AGGRECAN/VERSICAN PROTEOGLYCAN; 1.
DR Pfam; PF07686; V-set; 1.
DR Pfam; PF00193; Xlink; 4.
DR PRINTS; PR01265; LINKMODULE.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SMART; SM00445; LINK; 4.
DR SUPFAM; SSF56436; C-type lectin-like; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS01241; LINK_1; 4.
DR PROSITE; PS50963; LINK_2; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00323};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..672
FT /note="Aggrecan core protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018738664"
FT DOMAIN 23..146
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 150..245
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 250..347
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 439..534
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DOMAIN 539..636
FT /note="Link"
FT /evidence="ECO:0000259|PROSITE:PS50963"
FT DISULFID 196..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 294..315
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 485..506
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
FT DISULFID 583..604
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00323"
SQ SEQUENCE 672 AA; 74709 MW; 96E231BD5E146FD1 CRC64;
MTTLLLLCIS LPIILATTAL EEPDAIHVSI PVESPLRPLL GSKVQVPCYF HQNTVDDPGA
PTSAPLAHRI KWTYITKEKT AQILVATKGK ISVATEYLDR VTLVSYPQVP SDATIEITEL
SSKDSGTYRC EVTMGIEGSS DNVDIQVQGI VFHYRAISTR YTLTFDRAKE ACVMNGATIA
TPAQLQAAYD DGYHQCDAGW LSDQTVRYPI HEPREPCFGD KHNFPGVRTY GIRDVNETYD
VYCFAEKMSG RVFYSMSIDK FSFYEAKDQC VKLGARLATT GELYLAWKDG MDVCNAGWLA
DRSVRYPINI PRPQCGGGLV GVRTVYLYPN QTGYPYPDSR YDAICFQDNI LTPQRVTMKV
LCLGGPHPYL TSKPLWGGFI SLSIQIFGST VYDEILPLTL KSINSLHYNA ASLYVGAVHS
MTLLHKNTYE DQALLEEGVV FHYRPITGRY TLTFLEAQQA CQSIGAIIAS PQQLFAAFER
GLHQCDAGWL RDQTVRYPIV SPRENCAGNL PNLPGVRSYG QRPASERYDV YCYVGSLEGE
VFFTTDYDSF AYDEAVEHCQ KLNSTLATPG QLYAAWKRGL DKCRPGWLKD RSVRYPITTP
KSYCGGGQAG VHTIYTFPNQ TGFPDEHSRY DAYCFKGAFS SPVASIIAAL LQQPVNKQSA
AQPPVSFDWG PC
//
