ID A0A3Q2DM11_CYPVA Unreviewed; 905 AA.
AC A0A3Q2DM11;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Toll-like receptor 13 {ECO:0000313|Ensembl:ENSCVAP00000020317.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000020317.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000020317.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR RefSeq; XP_015230582.1; XM_015375096.1.
DR AlphaFoldDB; A0A3Q2DM11; -.
DR STRING; 28743.ENSCVAP00000020317; -.
DR Ensembl; ENSCVAT00000014660.1; ENSCVAP00000020317.1; ENSCVAG00000001622.1.
DR GeneID; 107084996; -.
DR KEGG; cvg:107084996; -.
DR GeneTree; ENSGT00940000164586; -.
DR OMA; YNNRLHF; -.
DR OrthoDB; 1207361at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 4.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..905
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018563068"
FT DOMAIN 748..893
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 905 AA; 102803 MW; 1BC36CE43DFFEA4E CRC64;
MVGAVLLLLL LNFPSYTAFG FMSCSQNFAD SHCMWCDNRK IVNISAVVRM FPENITFISF
SKNMIRVVPP GTFSRFAGLK HLDLSQNKLA FLKGEEFKGL HLLQFLNLTG NNMSLIHSNA
FEGLTGLKVL LLSRNSLLDV SGLLFHFFPA IESVDLSLNK LKSFSCEECG GSLSLKYLNL
SVNNIQKVNV SCFPALKYIK LSNNTQLELQ PDAFNSNQQL RTLLLQSVGV ESLMGLSAQT
RGDLIHISFS MFAENSSWTI CDVLRRMENV TKVEVDLKGS KLPESNTSLL DCPTPTMLIV
LQAQLGNVDR LSSEKSNTSK LYLINCGLKQ ISNATFQGFT ALKTLYLNQN HVNIKRDTFR
SLTKLTFLSL DRNRIRDIDS GWFHSLKGLT CLSLMKNEIT ELEANVFNAL TSLEQLYLQF
NLLRSLKKKT FGNLRRLKKL NLSLNIICFI EVGTFQDLTN LRYLDLSGNR IRRVTPFILS
GLQKLTALVL YNNRLEFRSY ESPFESLISL RFLEMRYQGP GGYGIGDIGP HFFKGLQNLT
CINIGNSVKM NIHPDAFTPL ISLKILFIDG VVLKETNLTA VLSPLKGLSK LMLHRADLDS
LPANLLPPNN SLKVLKVSSN HIRTLNKEML NNLPRLQYFD ISENPLSCDC DNAWFKTWAI
SNAHTQVSYL YNLKCNNERR SRYLWQFDDK TCSYDQISLT LFITCSVMDV LFVFVCLAWH
TQGPTLRFLL LMAKAKLRGR KRGAGVRFQY DAFISYSSKD EDWVMKQLVP NLEKPAAGAA
KLRLCLHHRD FRPGAAVLEN IEAAIYGSRH TICVVSHSYL QSEWCSVEFQ LASLRLLCDG
NDVLLMVFLE EIPEHCLSPY TRLRRIVHRR TYLLWPENPL EQNAFWVRLM DALRDSKGLK
EAGEF
//
