ID A0A3Q2DMH1_CYPVA Unreviewed; 834 AA.
AC A0A3Q2DMH1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Taste receptor type 1 member 2 {ECO:0000256|ARBA:ARBA00040704};
DE AltName: Full=Sweet taste receptor T1R2 {ECO:0000256|ARBA:ARBA00042616};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000020668.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000020668.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse
CC natural and synthetic sweeteners. {ECO:0000256|ARBA:ARBA00037659}.
CC -!- SUBUNIT: Forms heterodimers with TAS1R3.
CC {ECO:0000256|ARBA:ARBA00038699}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family. TAS1R
CC subfamily. {ECO:0000256|ARBA:ARBA00038492}.
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DR RefSeq; XP_015233237.1; XM_015377751.1.
DR AlphaFoldDB; A0A3Q2DMH1; -.
DR STRING; 28743.ENSCVAP00000020668; -.
DR Ensembl; ENSCVAT00000013780.1; ENSCVAP00000020668.1; ENSCVAG00000002172.1.
DR GeneID; 107086661; -.
DR KEGG; cvg:107086661; -.
DR CTD; 80834; -.
DR GeneTree; ENSGT00940000166394; -.
DR OMA; EDWAIST; -.
DR OrthoDB; 4096532at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; CALCIUM-SENSING RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24061:SF517; TASTE RECEPTOR TYPE 1 MEMBER 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Signal {ECO:0000256|SAM:SignalP}; Taste {ECO:0000256|ARBA:ARBA00022480};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..834
FT /note="Taste receptor type 1 member 2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018644309"
FT TRANSMEM 563..587
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 599..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 632..655
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 727..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 756..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 784..804
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 561..826
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 834 AA; 92231 MW; D976D673CB208351 CRC64;
MLTALLFSEW LMLQLAAGQL DYTSQAEGMQ IQGDYSLAGL FPLHYTDVDA GGLPALVPCN
QGRINKHGFH LLQAMRFAVE EINNGTGPLH LLPGVKLGYQ MYDICSNPAS VLATLDLLEQ
QYQSSSNTQK AVGVIGPDSS SKSFTPAALL GAYVIPQISY EASNEMLSNK NMYPAFFRTI
PSDKNQVAAM IQLLVRFNWR WIALLGSDND YGLQGMQSLS EQASQYGICI PYQGVIPTAS
DNTVQIMRNM VDNILKTKVN TIVVFSSKTR FHGFLPYVLE RNITGKVWIG TEDWSPSTLI
SGIPGIQSIG TVIGISVKDA SISGFDLFQK NMVDASMQHA QDDTNVSISS DNSCLQSRDL
YSIAKNNFSM DKYDITSSFN VYKAVYALAK ALHQALDCDS GECSKRSVTP PELLPLLRKV
RFSLSNSSVY FDVNGDPPTG YDIISWVWRG TEWSLRVVGS FSPDPITLTI DADLIEWHSK
GDSESEVPKS LCSPPCPTGH KKLQTGQHPC CFDCQPCPSA TFLNKSKPTE CQACLPEQWA
PPSSEECLNR TVILLEWDHP LSIALLFFLA TCLLLTFSTA IIHLVNLNTP VAKSAGGRTC
LLMLAALTVA ALSTLCHFGR PSPLACILKQ PLFTISFAVC LACITVRSLQ VVCIFKFSSK
LPPAYDKWMK KRGPEVTIFL VSVTMLFISV LRVSLDTPQP SQDLQFYHDK IVKECSKTLS
IGSGIELAYV SLLSVLCFAF SYMGKDLPAN YNEAKCVTFS LMVYMISWIS FFTLYLINRE
TFTMAAQVFA TLFSVLAFLA GYFLPKMYII VLRPHMNTTA HFQNCIQMYT MAKK
//