ID   A0A3Q2DNQ6_CYPVA        Unreviewed;       451 AA.
AC   A0A3Q2DNQ6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=FYVE, RhoGEF and PH domain-containing protein 4-like {ECO:0000313|Ensembl:ENSCVAP00000020394.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000020394.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000020394.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2DNQ6; -.
DR   Ensembl; ENSCVAT00000014461.1; ENSCVAP00000020394.1; ENSCVAG00000001751.1.
DR   GeneTree; ENSGT00940000155765; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd15741; FYVE_FGD1_2_4; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR000306; Znf_FYVE.
DR   InterPro; IPR017455; Znf_FYVE-rel.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF273; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 4 ISOFORM X1; 1.
DR   Pfam; PF01363; FYVE; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00064; FYVE; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50178; ZF_FYVE; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00091}.
FT   DOMAIN          1..145
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          294..354
FT                   /note="FYVE-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50178"
SQ   SEQUENCE   451 AA;  52087 MW;  133203BA5D9AEC2D CRC64;
     VIKNIFSNVS SIYSFHSQFL LPDMENCIMH WNESPGLGKA LLQHAPFLRM YADYIRNFDR
     AIELVRTWTE RSSAFRNIIH DIQSQEMCGN LTLQHHMLEP VQRVPRYELL LKDYLKKLPE
     DNPDYELASK SLEAISMAAT HSNSAIQKAE NLKRLLEIYE MVGEEEVVNP TNEFLKEGRL
     LKLAARNTSA MERQLFLFNN FVLCCSAKFS LVGQRFTVRC RIGVDGMQAQ QTTNEDHPYT
     FQVSGKEKTL ELQAIQEAVD VFEKKNESFK IASKELNAEP LKELGRRAPR WIRDNEVTLC
     MTCQEPFNAL TRRRHHCRAC GYVVCWKCSD NKVALEYDGN RLNKVCKACY SILAGQRTER
     MDRKKRRMVE SEVYPGSQDS VLSGFLQYGD SSMIWRQAWC VLTRTDPPLS PWGSRPMALT
     LSWVMVGSGL PATSLRVWKI RLFCSRKNLK K
//