ID A0A3Q2DSJ7_CYPVA Unreviewed; 407 AA.
AC A0A3Q2DSJ7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|Ensembl:ENSCVAP00000022876.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000022876.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000022876.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_015228899.1; XM_015373413.1.
DR AlphaFoldDB; A0A3Q2DSJ7; -.
DR STRING; 28743.ENSCVAP00000022876; -.
DR Ensembl; ENSCVAT00000008235.1; ENSCVAP00000022876.1; ENSCVAG00000005809.1.
DR GeneID; 107083884; -.
DR KEGG; cvg:107083884; -.
DR CTD; 122809; -.
DR GeneTree; ENSGT00940000166202; -.
DR OMA; KCDGACA; -.
DR OrthoDB; 5362214at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 249..344
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 339..388
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 28..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..56
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 407 AA; 45960 MW; 53E14380EB148E13 CRC64;
MSEKKPRGAD TRPKSGLRSW SADSYIWRGK KRSRSSRNGS SPSGMETDSS EELGVRSTSC
SRRRRERKCS CSALGDALTV GDIDGVCRKA LSRRSLRQKF QDAVGQCFPL RSHHHHHHHY
HHAGGSSRPF SVLFWSKRKI HVSELMQEKC PFSPKSELAK CWHLIKNQVA HPSSLKDMET
PLKASSISSS TSPPQTPLSW EDICCSPGPG GAPLEDWDPS SHHRGADGTC SNTDYILVPD
LLQINNNPCY WGVLNRFEAE ELLEGQPEGT FLLRDSAQDE FLFSVSFRRY SRSLHARIEQ
NGKRFSFDVR DPCMYRDPSV TGLLRHYSDP ATCLFFEPLL SRPLPRTFPF PLQHLCRAVI
CSCTTYQGVE SLPLPPQLRE YLRQYHIKCD RACAVSTPTA AGMQDLH
//
