ID   A0A3Q2DUG0_CYPVA        Unreviewed;       553 AA.
AC   A0A3Q2DUG0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Perforin-1-like {ECO:0000313|Ensembl:ENSCVAP00000023473.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000023473.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000023473.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC       {ECO:0000256|ARBA:ARBA00009214}.
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DR   AlphaFoldDB; A0A3Q2DUG0; -.
DR   STRING; 28743.ENSCVAP00000023473; -.
DR   Ensembl; ENSCVAT00000006682.1; ENSCVAP00000023473.1; ENSCVAG00000006809.1.
DR   GeneTree; ENSGT00530000063725; -.
DR   OMA; CICIANP; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.150; C2 domain; 1.
DR   InterPro; IPR000008; C2_dom.
DR   InterPro; IPR035892; C2_domain_sf.
DR   InterPro; IPR020864; MACPF.
DR   InterPro; IPR020863; MACPF_CS.
DR   PANTHER; PTHR46096:SF5; PERFORIN 1.3-RELATED; 1.
DR   PANTHER; PTHR46096; PERFORIN-1; 1.
DR   Pfam; PF00168; C2; 1.
DR   Pfam; PF01823; MACPF; 1.
DR   SMART; SM00239; C2; 1.
DR   SMART; SM00457; MACPF; 1.
DR   SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR   PROSITE; PS50004; C2; 1.
DR   PROSITE; PS00279; MACPF_1; 1.
DR   PROSITE; PS51412; MACPF_2; 1.
PE   3: Inferred from homology;
KW   Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..553
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018769772"
FT   DOMAIN          21..363
FT                   /note="MACPF"
FT                   /evidence="ECO:0000259|PROSITE:PS51412"
FT   DOMAIN          386..502
FT                   /note="C2"
FT                   /evidence="ECO:0000259|PROSITE:PS50004"
SQ   SEQUENCE   553 AA;  62053 MW;  37B4498DE8CD30E9 CRC64;
     MLLFWMWIPL SLPSTVSFIG SPQQCEKARF VPGYNLGGEG FDIVKMERKG AYVIDVETWN
     LGNGTCKMYR NSYLKGVNQK VPVAVVDWRT LPKCNMKVSN TLYDSVESLV KDSSSSVTND
     WKIGLNISLG NASASFSLGG SHSRVSKFGM AKSKEDRYSF ARQSVDCNLY RYRINTAPPM
     SPDFVSAVNS LPPYSSINRS PYQNLINIFG THYITQVYLG GEIAATTAFQ TCKATMEGLS
     ETEVSDCLWA EASASFANIS DQTTMAKHCK EKKKKMNGSQ SFGSKFNERI TEVVGGDEFG
     IVLFNVDSEP DVFKSWLNSL KTTPDIVQYN LNPIHMILPD NNHKKNGLKR EVEQYIMRNV
     VLKKCSESCQ IGHRSSKRDP CACVCNSNQN IKSNCCPAGK GLATLKVYKL YAKKLYGDTW
     SETDGSVEVK YGDQLKRTKI ILNNDNPSWP EKFDFGPIVI NMQNKLKFSV YDEDTNWNSD
     LLGQCSFDLR RGLVKDTCTF YHGTFYFTYL VECAPSLGGK RCDEYISSPM DPSLTKAFYT
     RNSVLLGNAM KMF
//