ID A0A3Q2DW03_CYPVA Unreviewed; 361 AA.
AC A0A3Q2DW03;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=SPARC {ECO:0000256|ARBA:ARBA00019049};
DE AltName: Full=Osteonectin {ECO:0000256|ARBA:ARBA00032081};
DE AltName: Full=Secreted protein acidic and rich in cysteine {ECO:0000256|ARBA:ARBA00031976};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000023094.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000023094.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Appears to regulate cell growth through interactions with the
CC extracellular matrix and cytokines. Binds calcium and copper, several
CC types of collagen, albumin, thrombospondin, PDGF and cell membranes.
CC There are two calcium binding sites; an acidic domain that binds 5 to 8
CC Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion
CC with a high affinity. {ECO:0000256|ARBA:ARBA00025574}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- SIMILARITY: Belongs to the SPARC family.
CC {ECO:0000256|ARBA:ARBA00006404}.
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DR AlphaFoldDB; A0A3Q2DW03; -.
DR STRING; 28743.ENSCVAP00000023094; -.
DR Ensembl; ENSCVAT00000007621.1; ENSCVAP00000023094.1; ENSCVAG00000006179.1.
DR GeneTree; ENSGT00510000046787; -.
DR OMA; CKGVRCG; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd16235; EFh_SPARC_SPARC; 1.
DR CDD; cd01328; FSL_SPARC; 1.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR003645; Fol_N.
DR InterPro; IPR015369; Follistatin/Osteonectin_EGF.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR001999; Osteonectin_CS.
DR InterPro; IPR019577; SPARC/Testican_Ca-bd-dom.
DR InterPro; IPR037641; SPARC_FS.
DR PANTHER; PTHR13866; SPARC OSTEONECTIN; 1.
DR PANTHER; PTHR13866:SF26; SPARC PRECURSOR; 1.
DR Pfam; PF09289; FOLN; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF10591; SPARC_Ca_bdg; 1.
DR SMART; SM00274; FOLN; 1.
DR SMART; SM00280; KAZAL; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS00612; OSTEONECTIN_1; 1.
DR PROSITE; PS00613; OSTEONECTIN_2; 1.
PE 3: Inferred from homology;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR637641-50};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 152..209
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT DISULFID 130..141
FT /evidence="ECO:0000256|PIRSR:PIRSR637641-50"
FT DISULFID 135..151
FT /evidence="ECO:0000256|PIRSR:PIRSR637641-50"
FT DISULFID 153..188
FT /evidence="ECO:0000256|PIRSR:PIRSR637641-50"
FT DISULFID 159..181
FT /evidence="ECO:0000256|PIRSR:PIRSR637641-50"
FT DISULFID 170..207
FT /evidence="ECO:0000256|PIRSR:PIRSR637641-50"
FT DISULFID 213..323
FT /evidence="ECO:0000256|PIRSR:PIRSR637641-50"
FT DISULFID 331..347
FT /evidence="ECO:0000256|PIRSR:PIRSR637641-50"
SQ SEQUENCE 361 AA; 40536 MW; 3E534C6163EF94C8 CRC64;
MQTGGDGRGL GDGGGKSHVH TGTSHWKCLL SKLVSQLDLP GAPHTADFSP HCPCSAKLKS
LKMRVWIVFL LCLAGHAIAA PTEEEPLVEE LVTEEAVVEE PEVGANPVQV EVGEFDEAIE
VDDVAAENPC LNYHCKKGKV CEVDESNTPL CVCQDPSTCP PAEGEFEHVC GTDNKTYDSS
CHFFATKCTL EGTKKGHKLH LDYIGPCKYI EPCLDTELNE FPLRMRDWLK NVLVTLYERD
EDNNLLTEKQ KLRVKKIYEN EKRLQAGDHS LDLLARDFKK NYNMFIFPVH WQFGQLDQHP
VDGYLTHSEL APLRAPLIPM EHCTTRFFET CDADGDKYIA LEEWASCFGI KEQDVDKDLI
I
//
