ID A0A3Q2DXD9_CYPVA Unreviewed; 763 AA.
AC A0A3Q2DXD9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Band 4.1-like protein 5 {ECO:0000256|ARBA:ARBA00023841};
DE AltName: Full=Erythrocyte membrane protein band 4.1-like 5 {ECO:0000256|ARBA:ARBA00030226};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000024417.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000024417.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in the formation and organization of tight
CC junctions during the establishment of polarity in epithelial cells.
CC {ECO:0000256|ARBA:ARBA00023750}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Photoreceptor inner segment
CC {ECO:0000256|ARBA:ARBA00004437}.
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DR RefSeq; XP_015254046.1; XM_015398560.1.
DR AlphaFoldDB; A0A3Q2DXD9; -.
DR STRING; 28743.ENSCVAP00000024417; -.
DR Ensembl; ENSCVAT00000004252.1; ENSCVAP00000024417.1; ENSCVAG00000008469.1.
DR GeneID; 107100169; -.
DR CTD; 57669; -.
DR GeneTree; ENSGT00940000156332; -.
DR OMA; XGKEQEH; -.
DR OrthoDB; 3682543at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008092; F:cytoskeletal protein binding; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13186; FERM_C_NBL4_NBL5; 1.
DR CDD; cd17205; FERM_F1_EPB41L5; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF15; BAND 4.1-LIKE PROTEIN 5; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 43..327
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 350..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 763 AA; 84191 MW; BE3771DE3BB7902B CRC64;
MLSFLRRTLG RRSIRKHAEK TRLREAQRAT THIPAAGDAT SIITCRVSLL DGTDVSVDLP
KKAKGEELFE QIMYHLDIVE KDYFGLRFMD SAQVPHWLDV TKSIKKQVKI GPPYCLHMRV
KFYSSEPNNL HEELTRYLFV LQLKQDILSG KLECPFDTAV ELAAFSLQAE LGDCDPLEHN
LDLVSEFRFI PEQTEEMELA IYNAWKECRG QMPAQAEINY LNKAKWLEMY GVDMHMVKAR
DGNEYSLGLT PTGVLVFEGQ TKIGLFFWPK ITRLDFKKSK LTLVVVEDDD QGKEQEHTFV
FRMDHPKACK HLWKCAVEHH AFFRLRGPVQ KNSARSGFIR MGSRFRYSGK TEYQTTKASK
ARRSASFERR PSRRYSRRTM QNRGQLHPQE VLSSGNGVSS NKGNKVSSSR SPWSGMPVVN
PPPASTCGPI EIEALPRSPG GEKRGLPVSP DLMETSIDDV LRAPAVPSIS AAEEVRPCAA
YAAASLPAED PLSLAEAAAR LKQLELESIP PPVTPRNNIN VNVAMNNQDN VVKLIEKCGL
NSAGNSPVVT PLRIPEDLKS NILKAQVEAA VLKGHLEEPV IMAADKNCNL QEASANSQPD
PQDSWELLKP ASLVSSAAAS AERLAEDLIP TVPKIPTVIE GLAPKVKAEE IEIQNVAVMS
DNLIDFTEPI PQLPPVQPPK PLITPRWIIP AAAPPGIFTN GLLDIEPSSK VVPLLPSADG
GAVLASAPVH LTHPRNPVTA SSAVQPPVME DGAKPRGLLT TEL
//
