ID A0A3Q2DZH7_CYPVA Unreviewed; 1058 AA.
AC A0A3Q2DZH7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 {ECO:0000313|Ensembl:ENSCVAP00000025336.1};
GN Name=RAPH1 {ECO:0000313|Ensembl:ENSCVAP00000025336.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000025336.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000025336.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2DZH7; -.
DR STRING; 28743.ENSCVAP00000025336; -.
DR Ensembl; ENSCVAT00000001883.1; ENSCVAP00000025336.1; ENSCVAG00000010068.1.
DR GeneTree; ENSGT00940000156552; -.
DR OMA; SMYNING; -.
DR Proteomes; UP000265020; Unplaced.
DR CDD; cd01259; PH_APBB1IP; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF15; RAS-ASSOCIATED AND PLECKSTRIN HOMOLOGY DOMAINS-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 96..205
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 237..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 636..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 959..1058
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 312..330
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..349
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..416
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..475
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..519
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 599..620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..688
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..769
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..847
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..880
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 921..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..981
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1058 AA; 112982 MW; 68221A6781D71D6B CRC64;
MKGSEVFRHP FLISSVKHVS LTAERIFEDH ENLVENLLNW TRDSQNRLMF TERIEKYALF
KNPQNYLLGR KETCEMAERN KEALLEECFG GSSVSVPEME GVLWLKEDGK KSWKKRYFLL
RASGIYYVPK GKAKTSRDLV CFLQLDHVNV YLGHDYKSKY KAPTDYCMVL KHPQIQKKSQ
YIKYLCCDDI RTLQQWINSI RIAKYGKQLY INFQEAMRRT EAAYDWSSLS SSSIKSGSSS
SSLPESQSNH SSQSDSGVSE LASSGHTRSQ SVVSSIFSDA WRRGTQGEMM KMDTISRPIP
VQIPSLSPQP QTPPSRSSYT DGLLPSEEDS SSPSPPSPPP PPPPVVGVAH QAAPPSSYVK
YSTLARLQSQ NQPRTQTPGG TSPASPPVQN FNTLPASYGT SPPSPPPPPP PTAPAPGSAM
AALKFGPPSP SSLPPPPLLE EEMQEPHCLP PPPPESLDAN GLPPPPPPEP LPNPCPQLSN
SGLQQFLSQK FPNMVYDFQP GALQDASPPP PPPPTELSPP NSLQALRPVS PNAPPPAPPK
TFSGVFAPLT APKPSGPSSL PIALSPVSPT QSFPGHGPVR KQQSFSTGHS PNQPPPTLPK
QHSLSSKNLS ISPSPSSSSI SIAAATSSLV KQIVNQFPGN SSPLPTSGSA PLSPPAVKAK
PKWQVGGAAA PQSPEFPPPP PDGSLGDFPP PPSSTSSSKT GSPIKKSPST SSTGSTKRGP
PPAPQRASSI KDAQDDRPKK VESLLSKFGQ APQTGTSSSS SSATGSPSKD SAPLPAPPPK
PGKLNLASLP LAIQGLQTGQ QQPDFPSPPL PPPPSHHPHL DSSADYFPPP PPESELFPPP
PHPSEFHHPP KVAVVNPQPQ MQSVTSSFSS STSSSWKQGS LKKGAAPPPA LNRRSSNTTA
QYDNTISLPL SPPPLSQTPP PSLSSYSASS SPIPPTSPKS AGPVSLALKP HFLEDLNRTL
KRKSVSRHGS LTSSTLIPSS KMEPVGTMDD MALLPPPPPE LLQQQQQGVR GHSHTLSRHH
GRSQSAKHGN ISGYATLRRG PPPAPPKRDQ STKLTSDW
//
