ID A0A3Q2DZL6_CYPVA Unreviewed; 600 AA.
AC A0A3Q2DZL6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Histone-arginine methyltransferase CARM1 {ECO:0000256|ARBA:ARBA00021804};
DE EC=2.1.1.319 {ECO:0000256|ARBA:ARBA00011925};
DE AltName: Full=Coactivator-associated arginine methyltransferase 1 {ECO:0000256|ARBA:ARBA00033236};
DE AltName: Full=Protein arginine N-methyltransferase 4 {ECO:0000256|ARBA:ARBA00030670};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000025277.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000025277.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) +
CC N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319;
CC Evidence={ECO:0000256|ARBA:ARBA00001817};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q2DZL6; -.
DR STRING; 28743.ENSCVAP00000025277; -.
DR Ensembl; ENSCVAT00000002045.1; ENSCVAP00000025277.1; ENSCVAG00000010021.1.
DR GeneTree; ENSGT00940000160377; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0048742; P:regulation of skeletal muscle fiber development; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd13330; PH_CARM1; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR020989; Histone-Arg_MeTrfase_N.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006:SF51; HISTONE-ARGININE METHYLTRANSFERASE CARM1; 1.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR Pfam; PF11531; CARM1; 1.
DR Pfam; PF06325; PrmA; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01015}; Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
FT DOMAIN 22..132
FT /note="Histone-arginine methyltransferase CARM1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11531"
SQ SEQUENCE 600 AA; 65895 MW; BC4596A0A40F745C CRC64;
QRVCTAAVGP LGGAPLLPSK MAVSVFRGVR LLSIGDANGD IQRHSEQQPL RLEVKTSQDA
ALINLSNEET SVFKCSVSRE TECSRVGKQS FIITLGCNSV LLQFSSPADF QSFYNLLKNC
RGHAGECSVF SERTEESSAV QYFQFYGYLS QQQNMMQDYV RTGTYQRAIL QNHTDFKDKV
VLDVGCGSGI LSFFAAQAGA RKVYAVEAST MAQHAEVLVN SNRLSERVVV IPGKVEEVSL
PEQVDIIISE PMGYMLFNER MLESYLHAKK FLKPNGKMFP TIGDVHLAPF TDEQLYMEQF
TKANFWYQPS FHGVDLSALR GAAVDEYFRQ PIVDTFDIRI LMAKSVKYTV NFLEAKEEDL
YRIEIPFKFH MMHSGLVHGL AFWFDVAFMG SVMTVWLSTA PTEPLTHWYQ VRCLLQSPLF
AKAGDTLSGT ALLVANKRQS YDISIVAQVD QTGSKSSNLL DLKNPFFRYT GTTPNPPPGS
HYSSPSENMW NTGAAYSMGQ GMAVSGMPTA YDLSTVIGSG PAASHNNLIP LVNTGIVNHT
HSRMGSIMST GIVQGATTGQ SGPSSSGTYY PITNQFTMGG AAISMASPMV IPSNTMHYGS
//