ID   A0A3Q2DZL9_CYPVA        Unreviewed;      1133 AA.
AC   A0A3Q2DZL9;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Rho GTPase-activating protein 39-like {ECO:0000313|Ensembl:ENSCVAP00000024439.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000024439.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000024439.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q2DZL9; -.
DR   STRING; 28743.ENSCVAP00000024439; -.
DR   Ensembl; ENSCVAT00000004184.1; ENSCVAP00000024439.1; ENSCVAG00000008542.1.
DR   GeneTree; ENSGT00940000164502; -.
DR   OMA; CTDSQGH; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04389; RhoGAP_KIAA1688; 1.
DR   Gene3D; 2.20.70.10; -; 1.
DR   Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   InterPro; IPR000857; MyTH4_dom.
DR   InterPro; IPR038185; MyTH4_dom_sf.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001202; WW_dom.
DR   InterPro; IPR036020; WW_dom_sf.
DR   PANTHER; PTHR45876; FI04035P; 1.
DR   PANTHER; PTHR45876:SF4; ZGC:92107; 1.
DR   Pfam; PF00784; MyTH4; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   SMART; SM00139; MyTH4; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00456; WW; 2.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF51045; WW domain; 1.
DR   PROSITE; PS51016; MYTH4; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50020; WW_DOMAIN_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT   DOMAIN          48..75
FT                   /note="WW"
FT                   /evidence="ECO:0000259|PROSITE:PS50020"
FT   DOMAIN          741..892
FT                   /note="MyTH4"
FT                   /evidence="ECO:0000259|PROSITE:PS51016"
FT   DOMAIN          940..1128
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   REGION          89..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          216..251
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          340..369
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..519
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          553..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          657..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..109
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..176
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        216..241
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        383..430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        440..454
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..492
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1133 AA;  125220 MW;  81A540560BD57720 CRC64;
     MAGASSDWVE ILEPRSRERM YVNLTTGECG WDPPPGVPVR QADGNQWWEL FDPHSGRFYY
     YNSTGRRTVW HRPQGADIVP LSQLQAMKRC SDARQAGGVS EDHHHRPTTG SIGSVRSQGR
     CTPLAERDGD SPLPTALEPS EPRAHSELDP AMDSRTKGDG SSTEHDTDDG KDPQRDNSQR
     WQPTPGSKAA MLVKVNSMPR SQPVPPLQHN THIKTSTASL HPSCSKSHGG HLNSSQGYKT
     APAGKMASDA RPAHHIRKTS NGSFCLVTSD SGHPSPLLHR SQTCTPRPVS PQYGCTAPIY
     DEPVLDCPIY DEPPTDMEVE GAHLYNGQPL SRLTPTQSLQ KPRLLPHPAS SHLGSRHRRD
     PSSSDYSPAG LECIKHMVNV DPKQGLPNSS PLPTRAASPT SRQDRVLTLP QSQPHPSQQS
     RGQSRDREPG TPGPSSLDKK HNWRILEATV QRAMDARHSR QSSQASQDFP STTPQATANY
     QDSGYSTGPS PSLRRKSRRR VGAGGVAGGR PGSVGSSGEL SALNERLMAE MREVVSRSNT
     MREVRAGLDP EMGERGVVPR TRSPADSLRW FGGGGSSTGR CPSQEDISGA PRALKGMANY
     GPSALTPVDV PGRQKRTYEK VDTLEMSINS QASLSSPETP GPPSQAGTLE LQAQLESRKK
     GMVDGRTASL GPHRSASHDN REGADGAGGR GGGSSYQLSY ATLRQPPPPD MGMEDWASKH
     LNMHTQGLFR RRVSIANMLS WNRGSIKKPM LVTSDRAIRK EACEMFKLVQ AYMGDRPSRL
     DRRHCALLIV TKCWDMPGLR DELYVQLVRQ TTGNASPRSL AAGWELMAVS LAFFAPSPKF
     RCYLEGYIQR HTEPNSDKKL TQFILEQQEL KLKKNSKSRK KRKQNTEEEE GLPISTYAKF
     CHRKLLKVAI TGGKKGLRKP TLEEIDHSRR AIITPSLFGS SLEEVMERQS ELFPDRKLPW
     VQVQLSQYVL ALGGAQTEGI FRVPGDIDEV NALKLQVDQW RIPENLTDPN VPASLMKLWY
     RELEEPLIPM DFYKQCISNC DDPVAAIAVV QSLPELNRLV LCYFIHFLQV FAQPSNVAIT
     KMDVNNLAMV MAPNCLRCHS DDPRIIFENT RKEMSFLRML IVHLDTGFIE GVV
//