ID A0A3Q2DZX0_CYPVA Unreviewed; 1145 AA.
AC A0A3Q2DZX0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Collagen type II alpha 1 chain {ECO:0000313|Ensembl:ENSCVAP00000025382.1};
GN Name=COL2A1 {ECO:0000313|Ensembl:ENSCVAP00000025382.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000025382.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000025382.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q2DZX0; -.
DR Ensembl; ENSCVAT00000001779.1; ENSCVAP00000025382.1; ENSCVAG00000015242.1.
DR GeneTree; ENSGT00940000155224; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 1.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR000885; Fib_collagen_C.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR24023; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24023:SF58; COLLAGEN ALPHA-1(II) CHAIN; 1.
DR Pfam; PF01410; COLFI; 1.
DR Pfam; PF01391; Collagen; 2.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00038; COLFI; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR PROSITE; PS51461; NC1_FIB; 1.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 4: Predicted;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1145
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018575116"
FT TRANSMEM 99..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..94
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 911..1145
FT /note="Fibrillar collagen NC1"
FT /evidence="ECO:0000259|PROSITE:PS51461"
FT REGION 215..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..328
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 639..653
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 858..875
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1145 AA; 113709 MW; 394455C67A1712EC CRC64;
MLSFMDSRTL LLLVASHVFL LAVVRCQRED NQEEDFICSQ DGQSYNDKDI WKPEPCRICV
CDKGMVLCDD IVCEELKDCP KPEIPFGECC PICAADQPSS FGLVLLSYLM MTGFIFPLQN
FAAQMAGGFD EKAGGGAQMG VMQGPMVRKR PCKMKSMGFI FFHCNIVISS TILHLTAQGA
RGFPGTPGLP GIKGHRGYPG LDGAKGETGA VGAKVGIGPR GLPGERGRPG STGAAGARGN
DGLPGPAGPP VGIILDIGEA GPTGARGPEG AQGPRGESGT PGSPGPSGAS VSNGIITNLN
RKKVGAPGIA GAPGFPGPRG PPGPQGATGP LGPKGTSGPV GPQGAPGPQG EEGKRGPRGE
PGAAGPLGPP GERVSNKGLR KQGAPGERGP PGTSGAKGAT GDPGRPGEPG LPGARGAPGE
DGRPGPPGPQ GARGQPGVMG FPGPKGATVS IFKCWCVPFQ GERGFPGERG AAGAQGLQGP
RGLPGTPGTD GPKGAIGPAG GPGAQGPPGL QGMPGERGAA GIPGPKGDRG DVGEKGPEGA
SGKDGARGLT GPIGPPGPAG PNGEKGESGP AGPSGPAGVR GAPVSGADGQ PGIKGEQGEA
GQKGDAGAPG PQGPSGAPGP AVRGATGFPG AAGRVGPPGP NGNPGPPGPA GSPGKDGPKG
VRGDGGPPGR QGDPGLRGPA GAPGEKGDAG EDGPPGPLGP SGPQGLAGQR GIVGLPGQRG
ERGFPGLPGP SGDRGNTGPA GAPGAPGAPG APGPVGPTGK QGNRGESGPQ GPRGDKGEGG
EAGERGQKGH RGFTGLQGLP GPPGQPGDQG ATGPAGPSGQ RGPPGPVGPA GKDGSNGLPG
PIGPPGPRGR TGDSGPAGPP GNPGPPGPPG PPGPGIDMSA FAGLGQTEKS PDPLRYMRAD
QAAGNLRQHD AEVDATLKSL NNQIENIRSP EGSKKNPART CRDLKLCHPD WKSGEYWIDP
NQGCTVDAIK VFCNMETGES CVNPRPAKIP RKNWWSSKSK DSKHVWFGET MNGGFHFSYG
DDSLAPNTAA IQMTFLRLLS TEASQNITYH CKNSVAYLDA SNSNLKKAVL LQGSNDVEIR
AEGNSRFTYS VMEDSCTRHT GQWGKTVIEY RSQKTSRLPI VDIAPMDIGG ADQEFGVDIG
AVCFL
//
