ID A0A3Q2E0E2_CYPVA Unreviewed; 562 AA.
AC A0A3Q2E0E2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Sorting nexin {ECO:0000256|PIRNR:PIRNR027744};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000025567.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000025567.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883, ECO:0000256|PIRNR:PIRNR027744}.
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DR RefSeq; XP_015253916.1; XM_015398430.1.
DR AlphaFoldDB; A0A3Q2E0E2; -.
DR STRING; 28743.ENSCVAP00000025567; -.
DR Ensembl; ENSCVAT00000001314.1; ENSCVAP00000025567.1; ENSCVAG00000010458.1.
DR GeneID; 107100074; -.
DR KEGG; cvg:107100074; -.
DR CTD; 257364; -.
DR GeneTree; ENSGT00940000160162; -.
DR OrthoDB; 5401713at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:InterPro.
DR CDD; cd07669; BAR_SNX33; 1.
DR CDD; cd11896; SH3_SNX33; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR037427; SNX33_BAR.
DR InterPro; IPR014536; Snx9_fam.
DR InterPro; IPR019497; Sorting_nexin_WASP-bd-dom.
DR PANTHER; PTHR45827; SORTING NEXIN; 1.
DR PANTHER; PTHR45827:SF3; SORTING NEXIN-33; 1.
DR Pfam; PF10456; BAR_3_WASP_bdg; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF14604; SH3_9; 1.
DR PIRSF; PIRSF027744; Snx9; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR027744};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR027744};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 1..61
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 218..328
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT BINDING 254
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-4,5-bisphosphate)"
FT /ligand_id="ChEBI:CHEBI:58456"
FT /evidence="ECO:0000256|PIRSR:PIRSR027744-1"
FT BINDING 256
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-4,5-bisphosphate)"
FT /ligand_id="ChEBI:CHEBI:58456"
FT /evidence="ECO:0000256|PIRSR:PIRSR027744-1"
FT BINDING 294
FT /ligand="a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
FT inositol-4,5-bisphosphate)"
FT /ligand_id="ChEBI:CHEBI:58456"
FT /evidence="ECO:0000256|PIRSR:PIRSR027744-1"
SQ SEQUENCE 562 AA; 64736 MW; CDC2028497292F0B CRC64;
MSVKGVAIYP FFSENKEEIS IQENEEVVIF DENSVDGWVL GENSRGERGL FPKSYVKIIR
TRSDSNVTDY SISPAGSIGK ESPNLPSTPN TSINSVQIYD EDYYDDWDDW DDRSTVVDDA
DNINVSSSGA NGHIYQAQSS NNPNVHYRSK AISRQDSIAS SRKGSMVGRN LNRFSSFVRS
GVEAFVLGDV PMMAKIAESY TIEMGPLGPQ WKANPQPFIC SVEDPTKQTK FKGIKTYISY
RVTPSHTGRP VYRRYKHFDW LYNRLLHKFT VISVPHLPEK QATGRFEEDF IEKRKRRLIL
WMNHMTSHPV LSQYEGFEHF LMCADDKQWK LGKRRAEKDE MVGAHFMLTL QIPNEHQDLQ
DVEERVDNFK TFAKKMDDSV MQLTNVASEL VRKHLGGFRK EFQRLGNAFQ SISHAFTLDP
PYKSDALNNA ISHTGCTYEN IGEMFAEQPK NDLFQMLDKL SLYQGLLANF PDIIHLQKGA
FAKVKESQRM SDEGKMDQDE ADGIRKRCRT VGFALQAEMS HFHQQREVDF KDMMQAYLRE
QIAFYQRVVQ QLERTLRMYD GL
//
