ID   A0A3Q2E1Y3_CYPVA        Unreviewed;       435 AA.
AC   A0A3Q2E1Y3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=GDNF family receptor alpha-4-like {ECO:0000313|Ensembl:ENSCVAP00000026147.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000026147.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000026147.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDNFR family.
CC       {ECO:0000256|ARBA:ARBA00005961}.
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DR   AlphaFoldDB; A0A3Q2E1Y3; -.
DR   STRING; 28743.ENSCVAP00000026147; -.
DR   Ensembl; ENSCVAT00000015973.1; ENSCVAP00000026147.1; ENSCVAG00000011496.1.
DR   GeneTree; ENSGT00940000160491; -.
DR   OMA; TTQMRKQ; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR   InterPro; IPR016017; GDNF/GAS1.
DR   InterPro; IPR037193; GDNF_alpha.
DR   InterPro; IPR003438; GDNF_rcpt.
DR   PANTHER; PTHR10269:SF2; GDNF FAMILY RECEPTOR ALPHA-4; 1.
DR   PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR   Pfam; PF02351; GDNF; 3.
DR   PRINTS; PR01316; GDNFRECEPTOR.
DR   SMART; SM00907; GDNF; 3.
DR   SUPFAM; SSF110035; GDNF receptor-like; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..435
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018711208"
FT   DOMAIN          34..113
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          151..231
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   DOMAIN          241..335
FT                   /note="GDNF/GAS1"
FT                   /evidence="ECO:0000259|SMART:SM00907"
FT   REGION          351..376
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  47805 MW;  C481082AC6184EEF CRC64;
     MALFSFLELI FLYVLPLCLT GVPHAVLSAG GRDCLRAGDT CSSDDTCSPR LRTLRQCVAG
     DGSMKLGPGA RNQCENAMTA LLSTPLHGCQ CKRGMKREKN CLSIYWSLHQ SVLHGLSLVE
     SYPYEPEERG SDYVRLASIA AESEVTTVNR CLDAAKACNI DETCQKLRTE YVSACIQPSA
     RSGPCNRPKC NKALRKFFDR VPPDYTHELL FCPCTDTACA ERRRQTIVPS CSYEEKDKPN
     CLAQLRDCKQ DYVCRSRWAQ FQYDCEASEH SASGCKRENH GSCLLAYTGL IGSTITPNYL
     DNSTSNVGPW CSCAASGNHR EQCNDFLAFF HDNVCLKNAI VAFGNGSDVK TGASQPGVTS
     PATDNESPHL ATTAPSISME TEQNVLRVSG NDRLWGDEGD STLPSPRLLD HSPEQVRLSM
     LLILGWLMLV LLCQP
//