ID A0A3Q2E3Z1_CYPVA Unreviewed; 1725 AA.
AC A0A3Q2E3Z1;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Rho GTPase activating protein 23 {ECO:0000313|Ensembl:ENSCVAP00000026931.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000026931.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000026931.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSCVAT00000017486.1; ENSCVAP00000026931.1; ENSCVAG00000012869.1.
DR GeneTree; ENSGT00940000157982; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF5; RHO GTPASE-ACTIVATING PROTEIN 23; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020}.
FT DOMAIN 40..149
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 807..924
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1016..1207
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 295..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 441..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 483..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 579..609
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..669
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 943..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1288..1368
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1398..1628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1643..1725
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..370
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 591..607
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..958
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1331
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1332..1357
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1446..1464
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1500..1544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1546..1567
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1585..1605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1670..1725
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1725 AA; 191187 MW; EF8A583029F4166D CRC64;
MDQAKGRRDG HSSTGDNPRP PMATRPGREG VGMGWKGPRT LVLHKNSQGF GFTLRHFIVY
PPESAMHTNL TDEENGNEKG YQKERLEPMD TIFVKNVREK GPAHKAGLCT GDRLVKVNGE
SVLGKTYSQV IALIQNSESV LELSIMPKDE DVLQLAYSQD AYLTGNEPFV GGAENLPPPP
PLCYPRTRTA PHPGAPLCSP MGQNQLDNWS CWPGSSSPSS PLDNRSGVAS PASWQEGQAG
EPGGVGHSSP AHRTEEIQYG MTSQQPQGQT RRRSYSSSSS SGGLVFSPLK VHYSNHQSAG
AAQAQPRKSS SAWTSPPMAP VPHSRNERCQ QALSDWYYNQ LPERSGRRMQ TRHRSYSQDR
LSEHRRQQQR AGGWPHSASQ DTLFLLQQSG QGPQGEPYWS AGDWEAGRER GRTDYTRTRS
ENLLAQYDRH GRSMEMLDRA SAGLVSPRSE RHPWPQQASQ PPHRTDAYPR PRCHTVVAQT
SAVPRLSHSK HHPQTHNQTQ SQQPAAQSKR LPAGQSMDEQ QVGYRSYSPS FNRKTGRILG
QAHSFRDPTY SGPHLNWNPV PKNGPAEGSS APLIASSSAL LTSVSPESKD RAYRPTNHER
ERRAVEGQGE MAVQTQEVVL RQKPPTGRRN PNRHPHYGIT MDELEPSLFS PEPKDTNVHP
GSAEELTPRK ANGNLAPLSL EEDSLASIPF IDEPTSPGAD LRARHVPASS VVSSGMSSAP
PVGTSPASPT FTFPLTRLFS HDCSITTERS KSCDEGLNTF REERTSRLPK RVKSFFGDGS
LDVIGTAEEV RSKRHSTSEL GNITYSDIRR EGWLQFKQIL TEKGKKVGSG IRPWKRVYSV
LRSHLLFLYK DKREAVLQGT SFGGAAEDEQ PINIRGCLVD IAYSETKRKH ALRLTTQDFC
EYLLQAEDRE DMLDWIKVIR ESNKTDSEEL GFSRQALISK KLNDYRKQSP TSSKPDSSPR
MHRMMPPFLL NKTENTAGAP RSPKPDGKDE SSPPKSPWGI NIMKKPKKSG PKAFGVRLEE
CQPGVNNKFI PLIVEFCCGL VEEMGLEYTG IYRVPGNNAI VSLLQEQLNK GMDINPAEER
WQDLNVVSSL LKSFFRKLPE PLFTNDKYID FIDANRMENA SERLKTMKKL IRDLPDHYFH
TLKFLITHLK TIADHSDKNK MEPRNLALVF GPTLVRTSED NMKDMVTHMP DRYKIVETLI
QHCVWFFTDE LDKDEKTPVD TEDVQPAPNI DHLLSNIGRT ALLGEASDST NSDSAKSKGS
WGSKKDLTAK DFLALSIMSA VSGRKRRKRH LARRIGSSTD DDSEHEPIKA GHLGMEEEEE
AESPVGDTAP RAEGEEDDED EEDDDDDEEE VVEGGVKEES EEELATVVSC QPCCKEEEEA
EGRQTAILLQ EEVVRAEVKE QPWKAPEDAR SIVSGYSTLS TLGRSLGSEG RGDEADDEHS
ELVSETDNES GFASRSLTQE RPSKQPTTPP NPQPSAPRSF LYSQCKPQVI LPTSPLTPPA
PITNTADSSE RSEGGARSNT PSSSSSSTAH RLHSRPSFNS HKLIQCDTLA RKKLKSEKAK
ARSLDLLESH SEGTGSGSEG APRPVKDSSR SNPSSGSSQE NLRLSRTRPA LPPSEAASFT
PTGPGGRSLA EHVRARLLGS ADDLRGVGLR KPPSPETRRK KRAWRRHTVV ASPTETSDKR
SPLTVNEFPL SPINQNQVKS RGADSLNQEP VTRQAPTSTL YHQYL
//