ID   A0A3Q2E5F3_CYPVA        Unreviewed;       835 AA.
AC   A0A3Q2E5F3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Actinin alpha 3 {ECO:0000313|Ensembl:ENSCVAP00000027377.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000027377.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000027377.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the alpha-actinin family.
CC       {ECO:0000256|ARBA:ARBA00010255}.
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DR   AlphaFoldDB; A0A3Q2E5F3; -.
DR   Ensembl; ENSCVAT00000029923.1; ENSCVAP00000027377.1; ENSCVAG00000013761.1.
DR   GeneTree; ENSGT00940000153968; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   CDD; cd21216; CH_ACTN_rpt2; 1.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd00176; SPEC; 1.
DR   Gene3D; 1.20.58.60; -; 4.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   PANTHER; PTHR11915:SF432; ALPHA-ACTININ-3; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   Pfam; PF00435; Spectrin; 4.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SMART; SM00150; SPEC; 3.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 4.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          1..83
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          92..198
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          694..729
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   DOMAIN          730..765
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   COILED          213..240
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          378..412
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          612..639
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   835 AA;  96158 MW;  F132204F133CC9A3 CRC64;
     LAKTPEPKGL INSTAWGPFL QSERLPKPDK GKMRFHKIAN VNKALDFICS KGVKLVSIGA
     EEIVDGNVKM TLGMIWTIIL RFAIQDISVE ETSAKEGLLL WCQRKTAPYR NVNVQNFHIS
     WKDGLALCAL IHRHRPDLID YSKLRKDDPI GNLNTAFEVA EKYLDIPKML DAEDIVNTPK
     PDEKAIMTYV SCFYHAFAGA EQAETAANRI CKVLAVNQEN EKLMEEYEKL ASELLEWIRR
     TIPWLENRVA EQTMRAMQQK LEDFRDYRRV HKPPRVQEKC QLEINFNTLQ TKLRLSNRPA
     FMPSEGKMVS DIANAWKGLE QVEKGYEEWL LTEIRRLERL DHLAEKFKQK CAMHEAWTGG
     KEDLLSQKDY ESASLMEIRA LMRKHEAFES DLAAHQDRVE QIAAIAQELN ELDYHDAATV
     NARCQGICDQ WDNLGTLTQK RRDALERVEK LWETIDQLYL EFAKRAAPFN NWMDGAMEDL
     QDMFIVHSIE EIQSLITAHD QFKATLPEAD KERMATIGIH NEILKIAQTY GIKLSGINPY
     TNLSQQDINN KWDTVKHLVP LRDQMLQEEV ARQQANERLR RQFAAQANII GPWIQTKMEE
     ISHVSVDIAG SLEEQMNSLK QYEQNIINYK SNIDKLEGDH QLSQESLIFD NKHTNYSMEH
     VRVGWEQLLT TIARTINEVE NQILTRDAKG ISQEQLNEFR ASFNHFDRKR NGMMDPDDFR
     ACLISMGYDL GEVEFARIMT LVDPNNTGVV TFQAFIDFMT RETAETDTAE QVMASFKILA
     SDKNYITVDE LRRELPPEQA EYCISRMTRY VGADAPPGAL DYISFSSALY GESDL
//