ID A0A3Q2E5N9_CYPVA Unreviewed; 592 AA.
AC A0A3Q2E5N9;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Complement C8 alpha chain {ECO:0000313|Ensembl:ENSCVAP00000027578.1};
GN Name=C8A {ECO:0000313|Ensembl:ENSCVAP00000027578.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000027578.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000027578.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the complement C6/C7/C8/C9 family.
CC {ECO:0000256|ARBA:ARBA00009214}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A3Q2E5N9; -.
DR STRING; 28743.ENSCVAP00000027578; -.
DR Ensembl; ENSCVAT00000018753.1; ENSCVAP00000027578.1; ENSCVAG00000013995.1.
DR GeneTree; ENSGT00940000160126; -.
DR OMA; CQPGVTI; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005579; C:membrane attack complex; IEA:UniProtKB-KW.
DR GO; GO:0006958; P:complement activation, classical pathway; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 1.
DR InterPro; IPR048831; C8A_B_C6_EGF-like.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR001862; MAC_perforin.
DR InterPro; IPR020864; MACPF.
DR InterPro; IPR020863; MACPF_CS.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR45742; COMPLEMENT COMPONENT C6; 1.
DR PANTHER; PTHR45742:SF1; COMPLEMENT COMPONENT C8 ALPHA CHAIN; 1.
DR Pfam; PF21195; C8A_B_C6_EGF-like; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF01823; MACPF; 1.
DR PRINTS; PR00764; COMPLEMENTC9.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00457; MACPF; 1.
DR SMART; SM00209; TSP1; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS00279; MACPF_1; 1.
DR PROSITE; PS51412; MACPF_2; 1.
DR PROSITE; PS50092; TSP1; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Complement pathway {ECO:0000256|ARBA:ARBA00022875};
KW Cytolysis {ECO:0000256|ARBA:ARBA00022852};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Membrane attack complex {ECO:0000256|ARBA:ARBA00023058};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..592
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018767550"
FT DOMAIN 147..506
FT /note="MACPF"
FT /evidence="ECO:0000259|PROSITE:PS51412"
FT COILED 481..508
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 107..119
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 126..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 592 AA; 66340 MW; AE7F29EC63193D23 CRC64;
MGALNYLILA LCVLHLFVNI NPTVNASRKP WRAANRRARA TNRLAPIDCK AGSWSSWTQC
DSCTDKKSRF RLLEKPAQFG GTDCIGMLWE QLVCPRATTQ CMVKDYCGES FTCKETGRCI
SQSLRCNGEP DCDDFSDEEQ CERINQRLDK CSTLMPIPGA ERSTQGYNVL TRDFMDPVLD
PKYFGGRCEY VYNGDWSKLI YDALCESLQY NEDEKNYRKP YNYHTYRFVA EATSKGSDEY
HEDLQSLLKA RETMSSVNSG VSVGIAFVEV GLSGSKESEF LNNITKYQSQ DFGFIRLWSK
VQTAHFKMRS NQLMLHEDLY VALMELPEQY DFGTYTRFLN TFGTHYVTEG TMGGTLEYVA
VLNKRAMAES NIDAKTFQKC FGVSLGITIP ASENSKFSFK VKINDCEKDK NIYKANSSES
AVVEDIITLV KGGVTETGSG LLAIRNQETY RKWGASLKYN PALIDFEILP IYEGLRLSTA
ADHASSRIDN LERAIDEYLQ QFDACRCAPC RHNGIPVLSG TSCSCVCKSG FQGMACEETL
RRDAKTDGSW SCWGSWSSCS SGTKTRTRIC NNPAPERGGA TCLGSASQTR QC
//
