ID A0A3Q2E6H0_CYPVA Unreviewed; 334 AA.
AC A0A3Q2E6H0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=SAM pointed domain containing ETS transcription factor {ECO:0000313|Ensembl:ENSCVAP00000027767.1};
GN Name=SPDEF {ECO:0000313|Ensembl:ENSCVAP00000027767.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000027767.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000027767.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR RefSeq; XP_015237229.1; XM_015381743.1.
DR RefSeq; XP_015237231.1; XM_015381745.1.
DR STRING; 28743.ENSCVAP00000027767; -.
DR Ensembl; ENSCVAT00000030146.1; ENSCVAP00000011982.1; ENSCVAG00000014366.1.
DR Ensembl; ENSCVAT00000030151.1; ENSCVAP00000027767.1; ENSCVAG00000014366.1.
DR GeneID; 107089144; -.
DR KEGG; cvg:107089144; -.
DR CTD; 25803; -.
DR GeneTree; ENSGT00940000157549; -.
DR OMA; VHYCAST; -.
DR OrthoDB; 3980839at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd08532; SAM_PNT-PDEF-like; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF182; SAM POINTED DOMAIN-CONTAINING ETS TRANSCRIPTION FACTOR; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 132..216
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 248..331
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
SQ SEQUENCE 334 AA; 38115 MW; FF4BC3463848C656 CRC64;
MSNPISGLPE STDFVPCIGM TEDSLILLER NRCSVDPWDT VDIKPNIEVL ERGVPSFYLS
CYDMLLTEEA ACLVKVSDGS SALAVHMNRM ESREEPEQCP VIDSQENGLS PGLEGQMEDR
SLEQVQSMVV GEVLKDIETA CKLLNITPDP TEWNTGNVQK WMLWTEHLYR LPHAGKAFQE
LTGKDLCAMS EEEFRQRSPL CGDTLHAHLD IWKSAAWMKD KCSAVDTKTT GSEELWSEAD
SSCSGQPIHL WQFLRELLLK PHNYGRSIRW LNKEKGIFKI EDSAHVAKLW GLRKNRPAMN
YDKLSRSIRQ YYKKGIIRKP DVSQRLVYQF VHPV
//
