ID A0A3Q2E789_CYPVA Unreviewed; 618 AA.
AC A0A3Q2E789;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|ARBA:ARBA00012644, ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN Name=GALNT8 {ECO:0000313|Ensembl:ENSCVAP00000028188.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000028188.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000028188.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922, ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU361242}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU361242}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|RuleBase:RU361242}.
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DR RefSeq; XP_015231684.1; XM_015376198.1.
DR AlphaFoldDB; A0A3Q2E789; -.
DR STRING; 28743.ENSCVAP00000028188; -.
DR Ensembl; ENSCVAT00000019948.1; ENSCVAP00000028188.1; ENSCVAG00000015059.1.
DR GeneID; 107085707; -.
DR KEGG; cvg:107085707; -.
DR CTD; 26290; -.
DR GeneTree; ENSGT00940000160161; -.
DR OMA; MTFWRKR; -.
DR OrthoDB; 202750at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF50; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 8-RELATED; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|RuleBase:RU361242};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361242}.
FT DOMAIN 159..287
FT /note="Glycosyltransferase 2-like"
FT /evidence="ECO:0000259|Pfam:PF00535"
FT DOMAIN 472..596
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|Pfam:PF00652"
FT COILED 56..93
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 618 AA; 71096 MW; A16DC8928E200B8A CRC64;
MRSGWFKAFL MVIAVASGLV YLSSIKAELS THSERLHRAQ HNESLRGQGM MMMRRMEMME
KDINRLMSLM KHYEKKEQGL DKAKKEKKRV MKLFPDSHLF RKWGDDLSEE EQKEAEDLFQ
RYGYNAFLSD RLPINREIPD TRPPRCAEKR YPEDLPSLSV ILIYLDEALS VIKRAIRSII
DRTPPRLLLE IILVDDHSSN DDLLGKLDEY ISSIHEERPG LVKKIHHSEQ LGLTQARLSG
WKAAVGDVVA ILDAHIEVHV QWAEPLLARI KEDRTVILTP VFDKISFDDL IPIPYGTSAH
GFDWAMWCMY EGFRPEWYAL RDDSQPGKSP SVMGILVAER KFFGEIGSLD GGMKIYGGEN
VELGIRVWLC GGSIEIIPCS RIAHIERFHK PYARDLSSFV RRNALRVAEV WLDDYKYNVE
VAWNLPIGNH GIDIGDVSER KKLKEKLKCK PFQWYLDNVY PMLEPMSNLL GYGALINDLL
PDQCVDRGPV PGFIPILHGC HFFTPQHCHY HTDGTLHIGG FKSHKYDSSD CLLDPGLGAL
PGLYQCRMAE QKKLHMFWDF KQGGQIQNRE TKRCLEISMR GLNLKLVLQQ CSGQRWKLQH
VVDVTAQKLH RLSEKLVL
//
