ID A0A3Q2E7C6_CYPVA Unreviewed; 510 AA.
AC A0A3Q2E7C6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=2-phosphoxylose phosphatase 1 {ECO:0000256|ARBA:ARBA00040357};
DE AltName: Full=Acid phosphatase-like protein 2 {ECO:0000256|ARBA:ARBA00041499};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000027394.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000027394.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-O-[beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-
CC beta-D-2-O-P-Xyl]-L-seryl-[protein] + H2O = 3-O-(beta-D-GlcA-(1->3)-
CC beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] +
CC phosphate; Xref=Rhea:RHEA:56512, Rhea:RHEA-COMP:12573, Rhea:RHEA-
CC COMP:14559, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:132093,
CC ChEBI:CHEBI:140495; Evidence={ECO:0000256|ARBA:ARBA00036311};
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the histidine acid phosphatase family.
CC {ECO:0000256|ARBA:ARBA00005375}.
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DR RefSeq; XP_015251282.1; XM_015395796.1.
DR AlphaFoldDB; A0A3Q2E7C6; -.
DR Ensembl; ENSCVAT00000018410.1; ENSCVAP00000027394.1; ENSCVAG00000013694.1.
DR GeneID; 107098249; -.
DR CTD; 92370; -.
DR GeneTree; ENSGT00390000016324; -.
DR OMA; DWEWNYY; -.
DR OrthoDB; 3403603at2759; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07061; HP_HAP_like; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR033379; Acid_Pase_AS.
DR InterPro; IPR000560; His_Pase_clade-2.
DR InterPro; IPR029033; His_PPase_superfam.
DR PANTHER; PTHR11567:SF125; 2-PHOSPHOXYLOSE PHOSPHATASE 1; 1.
DR PANTHER; PTHR11567; ACID PHOSPHATASE-RELATED; 1.
DR Pfam; PF00328; His_Phos_2; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00616; HIS_ACID_PHOSPHAT_1; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022968}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..510
FT /note="2-phosphoxylose phosphatase 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018710137"
SQ SEQUENCE 510 AA; 57615 MW; D4EA304A6C4C2970 CRC64;
MLLSQTGHLS FLFFIVSVNL IPTTPMQDER PVHAADGPVR ALQVKSRKRV FPVRPTMEPD
PVLEAYSYCN TPNRTEQAWE GHSPADYKLL SVHVMIRHGD RYPLYSIPKT KRPSIDCTLS
ASREPPHPLL NRFVNHMSQG TRGHWESPLG SISRLPNHSA CEMGELTQTG VVQQLINGQI
LHHAYKHHGL LPSDWSPRQV WMETTGKSRT LQSGMAFLYG FLPDFNWTKL TVRHQWSTLF
CGAACECPAR NRYLEEEQRR QYRLRVADAN LEKTYVDMAR TLGVPTRQLR AANPMDSLLC
HLCHGLSFPC VPSGAGGSGG CLTVAQFAVI RQQQLDNEVD RRRVGVYRKY AILAMYPYLN
RTANKMERVA KASKAGLRPA AGGEEVFTLS SGHDVTMAPL LSALGLEEAK FPRFAARIVF
EMWRSPPTTK VPVKKRGKGE RANLKDGEVF IRVLYNGEDV TFHTAFCHPA ARHVSQPLCP
LRNFLTFIRK DMFSILNATS YKDACFKHFE
//
