ID A0A3Q2E7W2_CYPVA Unreviewed; 1735 AA.
AC A0A3Q2E7W2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Dedicator of cytokinesis 5 {ECO:0000313|Ensembl:ENSCVAP00000028311.1};
OS Cyprinodon variegatus (Sheepshead minnow).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC Cyprinodon.
OX NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000028311.1, ECO:0000313|Proteomes:UP000265020};
RN [1] {ECO:0000313|Ensembl:ENSCVAP00000028311.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 28743.ENSCVAP00000028311; -.
DR Ensembl; ENSCVAT00000020172.1; ENSCVAP00000028311.1; ENSCVAG00000015344.1.
DR GeneTree; ENSGT00940000157734; -.
DR OMA; GHTAWRT; -.
DR Proteomes; UP000265020; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF3; DEDICATOR OF CYTOKINESIS PROTEIN 5; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 7..68
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 442..609
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1211..1622
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1655..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1713..1735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1735 AA; 200488 MW; B333B4E786E997F7 CRC64;
YVAVSTTNRQ KWNSIYNYDP RGEQELRLQV GDTVHILEKF EGWYRGYTLR KKAHKGIFPA
SYIHLKEATV EGIGQQEIII PADIPLVQEI GATLREWVQI WQKLYVANKI TKFRSVQQMA
YSLIEYRSQI VSGTLPKDDL VELKKKVTAK IDYGNRILGL DLVVRDEAGN MLDPDWTSTV
RLFQAHETAS RSVDDRIQEE KTRLQNMEMR RQTLFSSVHT YSLLMNLKNF VCNIGEDAEL
LMSLYDPDQS EFISENFLVR WDSMGMPKEI EKLNNLPALF TDLSSSDLMR QRLFLVCQII
RVGSMELKEG KKQTGGLRRP FGVAVMDVTD IAHGKVDDED KQHFIPFQQI AMETYIRQRQ
LIMSPLIPSR VIGENEPLTA VFNKVIATRD VNHKGQGLFV TLKLLPGDLP QVRKDFPHFV
DRSTAIVGKM GFPEIILPGN VRNDIYVTLL QGEFDRGKKK TPKNVEVILS VHDDEGNPME
KAIFPGAGYD GITEYKSVIY YQVKQPCWNE TVKVTIPIED VCRCHLRLPF GMAFVKLMRG
DGTTLKDGRH ELIVYKVDVK KAEDAKLYLT LPATWAEVEQ MEKQTGKQFH HSGAIPVTKD
SFQLATLTCS TKLTQNVDLL GLLNWRSKHE DLDQILQRLM EVEGGEIVKF LQDTLDALFN
IMMETSEKDT YDTLVFDALV FIITLIGDIK FQHFNPVLET YISKHFSATL AYTKLTKVLN
YYVGHPEEPT LTERLYTALK ALKYLFRFIV QSRVLSFRFP ENSEDPDAFF NSIRMLFLSF
NTLMDRPLDE GVKIKGAILK YLPSIINDIQ TVFDPVELSV LLAKFIESIP DSQFVRQKLG
CLCKIIESDL FTQPDCRDVL LPLVTDQLSG QLDDYSSKPD YEACVQLLST VLDTLDRKDV
GPTRVHIQLI MERLLRRVNR TVISMDRSSP LIGHYLACMT AILKQMDDMH YTHYISTFKT
RQDIIDFLME TFIMFKDLMG NVFPADWMVM NLVQMQVFLR AINQYSDVLN KLFLDQAHFE
LQLWNNYFHL TVAFLTHKTL QLESFSQEKR NKILNKYGDM RKTMGFRIRD MWYNIGPHKM
KFIPSMVGPI LEVTLVPEPE LRKDTIPIFF DMMQCEHNFS KTRTFETFEN ELITKLDQEV
EGGRGDEQYK VLLEKILLEH CRRHRYLSQS GEELALLLSS LLENLLAYRT ITHDESPERR
MSCTVNVLNF YKEKKREDIY IRYLYKLRDL HLDCENYTEA AYTLLLHAEL LEWSDKPCAP
HLIPRDGSHV WTQQELKERL FQEIICYLDK GKMWEKAIEL GKQLAKMHES HMFDFMELSE
LLKKQAKFYE QILHAMRPQP EYFAVGYYGL GFPSFLRNKM FIYRGKEYEW LEDFSLKLLS
QFPNAVRMTS TAPPGDDISN SPGQHIQCFT VKPVLTLPQK FKDKGVPEQI LNYYRYNEVD
QFQYSRPFRK GEKDPDNEFA TMWIERTTYI TAYRFPGILK WFEVKSVSVV EISPLMNAIE
TMEMANEKLS NLVQQQACDR SLSINPLSMM LSGIVDPAVM GGFSNYEKAF FTDTYIQEHP
EDHDRIEVLK QLIALQIPLL EDGIRIHGEK ATEQLRPLHN RLVTCFQDLR EKVEKLYGVI
TLPCSLTEKK KSRVGSVVVP YILSSTLRRM STASTLSSTS SGLSSGSASS DGPSSQESVP
LHPHFINVKK TYFFILVLTQ TFFCPPPQFS PPLPVKIESK PPPPPPKTRK SMLPS
//