ID   A0A3Q2E850_CYPVA        Unreviewed;       976 AA.
AC   A0A3Q2E850;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Klotho {ECO:0000313|Ensembl:ENSCVAP00000027739.1};
GN   Name=KL {ECO:0000313|Ensembl:ENSCVAP00000027739.1};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000027739.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000027739.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_015235554.1; XM_015380068.1.
DR   AlphaFoldDB; A0A3Q2E850; -.
DR   STRING; 28743.ENSCVAP00000027739; -.
DR   Ensembl; ENSCVAT00000030128.1; ENSCVAP00000027739.1; ENSCVAG00000014318.1.
DR   GeneID; 107088119; -.
DR   KEGG; cvg:107088119; -.
DR   CTD; 9365; -.
DR   GeneTree; ENSGT00940000157614; -.
DR   OMA; HVSHFHF; -.
DR   OrthoDB; 3373839at2759; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   GO; GO:0040016; P:embryonic cleavage; IEA:Ensembl.
DR   Gene3D; 3.20.20.80; Glycosidases; 2.
DR   InterPro; IPR001360; Glyco_hydro_1.
DR   InterPro; IPR033132; Glyco_hydro_1_N_CS.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR   PANTHER; PTHR10353:SF10; KLOTHO; 1.
DR   Pfam; PF00232; Glyco_hydro_1; 3.
DR   PRINTS; PR00131; GLHYDRLASE1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 2.
DR   PROSITE; PS00653; GLYCOSYL_HYDROL_F1_2; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..976
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018709499"
FT   TRANSMEM        944..967
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   976 AA;  112122 MW;  D2BC9D30D286820C CRC64;
     MGGHLALLTF LALSSAAAKP QAGLKTWGRF SKLPYPGDKA FLYRTFPQDF IWAVGTAAYQ
     VEGAFEKDGK GLSIWDTFTR GGNRMATGDV GSDSYHNIHA DIRAIRQLGV SHYRFSLSWS
     RIFPNGTRGS YNEIGTNYYR TLIKKLKEIR VQPVVTLYHW DLPEHLQQSL GGWSNPQLVH
     IFKDYADFCF QEFGDDVKYW ISIDNPFVVA QHGYGTGVIA PGIKNDPDLP FRVGHNLLKA
     HAATWHLYNR HYRPRQQGKL SMALASHWIK PSRTRLESLR ECQCSLDHVL GWFARPLFVD
     GDYPPCMRER LGSRLPSFTQ EEREQVRGTA DFFALSHGAT LSFQLNDSLK FGQLEDLDLR
     MLLYWVNAEY DKPPIFVVQS GWFVLGNTKT EDPKHMYYLK RFIAEALKSI ILDGVNLIGY
     TAWSLIDGFE WHREYGIRRG LYYVDFNTPD MKREPKTSAT FYRNVIHKNG FPELPENRPA
     QGVFPCDFAW GVSANSIQVE TTPTQFADPN IYLWNISNNG ELIKLEGFSA PPLHRATHCA
     DYATIRQQVD EIRQVGVNHF HFSLNWSALV PTGDVAYPNS TLLGYYRCFT QQLLQANVTP
     VVTLWHHTHE RSSLPPPLDT ANRWLNRKTP EAFADYARLC YRELGTHVKM WITLNEPNDK
     MVNYQEGHQM LRAHALAWHV YDREFRRTQG GKVSLALHMD WVEPAFSFSR EDVEPAKRVL
     DFNVGWLAEP IFGSGDYPMG MRSWLRQLNS LELPVFNEED RQLVMGTYDF FAMSHFSTEL
     VTHAKEDSYT YTEMLEVQRM IDTTWIMSPL PVVPWGLRKA LNWVKQHYGD VPIYIMANGV
     EEDPARFKDS LRVYYLYNYI NEALKAFTLD GVNLKGYFAY ALNDQRDLGF GLYGQVHEEV
     IVKASLSNYR NIIQHNGFPI PGAPPQQCPA LPQPCPGCHL LIRWPVIGFM SLVGSGVLIM
     LGLIIYYSTK RQKEYY
//