ID   A0A3Q2E8H3_CYPVA        Unreviewed;       329 AA.
AC   A0A3Q2E8H3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Ion channel TACAN {ECO:0000256|ARBA:ARBA00039635};
DE   AltName: Full=Transmembrane protein 120A {ECO:0000256|ARBA:ARBA00041456};
OS   Cyprinodon variegatus (Sheepshead minnow).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Cyprinodontidae;
OC   Cyprinodon.
OX   NCBI_TaxID=28743 {ECO:0000313|Ensembl:ENSCVAP00000028482.1, ECO:0000313|Proteomes:UP000265020};
RN   [1] {ECO:0000313|Ensembl:ENSCVAP00000028482.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Nucleus inner membrane
CC       {ECO:0000256|ARBA:ARBA00004473}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004473}.
CC   -!- SIMILARITY: Belongs to the TMEM120 family.
CC       {ECO:0000256|ARBA:ARBA00009700}.
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DR   AlphaFoldDB; A0A3Q2E8H3; -.
DR   STRING; 28743.ENSCVAP00000028482; -.
DR   Ensembl; ENSCVAT00000030588.1; ENSCVAP00000028482.1; ENSCVAG00000015705.1.
DR   GeneTree; ENSGT00390000007848; -.
DR   OMA; WELYNSI; -.
DR   Proteomes; UP000265020; Unplaced.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012926; TACAN/TMEM120B.
DR   PANTHER; PTHR21433:SF1; ION CHANNEL TACAN; 1.
DR   PANTHER; PTHR21433; TRANSMEMBRANE PROTEIN INDUCED BY TUMOR NECROSIS FACTOR ALPHA; 1.
DR   Pfam; PF07851; TMPIT; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000265020};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        127..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        154..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        184..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        250..268
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        280..303
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   329 AA;  38734 MW;  FD53047A1804BC26 CRC64;
     MLFSPNDLSE CLREWDDLEK DYQQIQDTHR LYKQKLEEVS KLQTSCSSAI ARQRKKLGEL
     TLSLKGSIES IAEMEESIKD KTNVFFEMEA FLPKKNGLYL TLVLGNINVT LLNKQAKFAY
     KDEYEKFKLV LTVILFVFSF TCRFLFSYRV LDALFNFLLV WYYCTLTIRE SILISNGSRI
     KGWWVFHHYV STFLSGVMLT WPDGALYQMF RNQFLSYNLY QSFVQFLQYY YQSGCLYRLR
     ALGERHTMDL TVGIPQLLFI CALPLEIWRV CNRLIQSHSS FPACVFLCFA IQVLMCGCSY
     MVLFMGNLFT TLRVVYQKYM NNEDKSKSM
//